Methodology for the metric restoration of the historical cartography applied to Francisco Coello's cartografic series of the Royal Site of Aranjuez

Hojas Kilométricas (Kilometric Sheets). Specifically, the study focuses on those sheets referring to the city centre and surrounding area of the Royal Site of Aranjuez, a town in the south of the Province of Madrid. The aim of this study is to restore the actual size and measurements of scanned images of the Hojas Kilométricas. This would allow us, among other things, to reestablish both the format and scale of the original plans. To achieve this goal it is necessary to rectify and then georeference these images, i.e. assign them a geographic reference system. This procedure is essential in the overlaying and comparison of the Hojas Kilométricas of the Royal Site with other historical cartography as well as other sources related to the same area from different time periods. Subsequent research would allow us, for example, to reconstruct the time-evolution of the urban area, to spot new construction and to pinpoint the locations of any altered or missing buildings or architectural features. In addition, this would allow us to develop and integrate databases for GIS models applicable to the management of our cultural heritage.

Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.

The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.

The involvement of thaumatin-like proteins in plant food cross-reactivity: a multicenter study using a specific protein microarray.

Cross-reactivity of plant foods is an important phenomenon in allergy, with geographical variations with respect to the number and prevalence of the allergens involved in this process, whose complexity requires detailed studies. We have addressed the role of thaumatin-like proteins (TLPs) in cross-reactivity between fruit and pollen allergies. A representative panel of 16 purified TLPs was printed onto an allergen microarray. The proteins selected belonged to the sources most frequently associated with peach allergy in representative regions of Spain. Sera from two groups of well characterized patients, one with allergy to Rosaceae fruit (FAG) and another against pollens but tolerant to food-plant allergens (PAG), were obtained from seven geographical areas with different environmental pollen profiles. Cross-reactivity between members of this family was demonstrated by inhibition assays. Only 6 out of 16 purified TLPs showed noticeable allergenic activity in the studied populations. Pru p 2.0201, the peach TLP (41%), chestnut TLP (24%) and plane pollen TLP (22%) proved to be allergens of probable relevance to fruit allergy, being mainly associated with pollen sensitization, and strongly linked to specific geographical areas such as Barcelona, Bilbao, the Canary Islands and Madrid. The patients exhibited mayor que50% positive response to Pru p 2.0201 and to chestnut TLP in these specific areas. Therefore, their recognition patterns were associated with the geographical area, suggesting a role for pollen in the sensitization of these allergens. Finally, the co-sensitizations of patients considering pairs of TLP allergens were analyzed by using the co-sensitization graph associated with an allergen microarray immunoassay. Our data indicate that TLPs are significant allergens in plant food allergy and should be considered when diagnosing and treating pollen-food allergy.

Discurso de investidura como Doctor Honoris Causa del Profesor Doctor D. Enrique Alarcón [Universidad Carlos III]

Sean mis primeras palabras de agradecimiento a la Universidad Carlos III y en particular a los Departamentos de Mecánica de los Medios Continuos y de Matemáticas por el honor concedido al otorgarme el grado de Doctor. Honor debido, más que a méritos propios, a la amistad con que siempre me han distinguido el equipo rectoral, y los compañeros de los Departamentos citados especialmente los profesores Carlos Navarro y Francisco Marcellán con los que he tenido la fortuna de compartir ideales de enseñanza e investigación. La Universidad Carlos III fue creada en un esfuerzo por redistribuir los nuevos núcleos culturales en zonas tradicionalmente utilizadas como ciudades-dormitorio, contribuir a su desarrollo, descentralizar los focos de saber establecidos y provocar la competencia intelectual mediante la incorporación de profesores jóvenes y en posesión de experiencia internacional. Todo lo ha cumplido con exceso en las diferentes ramas del saber a que se dedica y ello, unido a una intensa actividad cultural paralela, la ha transformado en uno de los polos más atractivos para la juventud estudiosa y el mundo científico de la Comunidad de Madrid. En la medida de mis posibilidades y desde su fundación he colaborado con la Universidad en la búsqueda de profesores adecuados y en el análisis de la evolución de sus grupos de ingeniería. Si antes la motivación estribaba en la curiosidad intelectual ante una experiencia tan interesante como el desarrollo ex novo de una Universidad, ahora mi interés estará reforzado por el agradecimiento a esta distinción y por la deuda de gratitud a la que sólo puedo corresponder ofreciendo públicamente mi disponibilidad a colaborar con aquélla en lo que se considere pueda ser útil.

Initial design with L2 Monge-Kantorovich theory for the Monge–Ampère equation method of freeform optics

The Monge–Ampère (MA) equation arising in illumination design is highly nonlinear so that the convergence of the MA method is strongly determined by the initial design. We address the initial design of the MA method in this paper with the L2 Monge-Kantorovich (LMK) theory, and introduce an efficient approach for finding the optimal mapping of the LMK problem. Three examples, including the beam shaping of collimated beam and point light source, are given to illustrate the potential benefits of the LMK theory in the initial design. The results show the MA method converges more stably and faster with the application of the LMK theory in the initial design.

The Monge-Ampére equation method in freeform optics design

The Monge-Ampére equation method could be the most advanced point source algorithm of freeform optics design. This paper introduces this method, and outlines two key issues that should be tackles to improve this method.