6 resultados para GLUTATHIONE DERIVATIVES

em Universidad Politécnica de Madrid


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The efficiency of the Iberian Energy Derivatives Market in its first five and a half years is assessed in terms of volume, open interest and price. The continuous market shows steady liquidity growth. Its volume is strongly correlated to that of the Over The Counter (OTC) market, the amount of market makers, the enrolment of financial agents and generation companies belonging to the integrated group of last resort suppliers, and the OTC cleared volume in its clearing house. The hedging efficiency, measured through the ratio between the final open interest and the cleared volume, shows the lowest values for the Spanish base load futures as they are the most liquid contracts. The ex-post forward risk premium has diminished due to the learning curve and the effect of the fixed price retributing the indigenous coal fired generation. This market is quite less developed than the European leaders headquartered in Norway and Germany. Enrolment of more traders, mainly international energy companies, financial agents, energy intensive industries and renewable generation companies is desired. Market monitoring reports by the market operator providing post-trade transparency, OTC data access by the energy regulator, and assessment of the regulatory risk can contribute to efficiency gains.

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High temperatures and relative humidity can compromise animal welfare on the farm level, but less is known about those changes during long distance transport of domestic animals to slaughter. Although upper temperature limits have been established to transport pigs in Europe, few indices include relative or absolute humidity maxima or mention appropriate enthalpy ranges.

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In hot Spanish climate, Toledo, Syrah and Sauvignon blanc Vineyard were treated in pre veraison with yeast derivatives RD-LM and RD- LA to stimulate phenolic and aromatic maturity respectively (application of yeast derivatives specifically designed to be used with the patent foliar application technology WO/2014/024039, Lallemand Inc. Canada). For studied effects in berry and wine composition three harvest time had been done. Experimented yeast derivatives had no significant effects on yield components and vegetative growth in both varieties. The Syrah RD-LM variety presented higher total and extractable anthocyanins and also more amount of tannins, although this last ones are not evident in the sensory analysis. The sensory analysis of wine has given very similar results in both varieties but with significant results in favored by phenols and tannins derived RD- LM and RD-LA respectively.

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Induced defense responses in plants usually involve biosynthesis of antimicrobial metabolites and their targeted secretion at the site of pathogen contact. Our recent study on the model plant Arabidopsis revealed a novel pathogen triggered metabolism pathway for glucosinolates, amino acid-derived thio-glucosides characteristic for crucifer plants that so far were mainly known as insect deterrents (Bednarek et al. 2009).

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The effect of the addition of a commercial enriched glutathione inactive dry yeast oenological preparation in the volatile and sensory properties of industrially manufactured rosé Grenache wines was evaluated during their shelf-life. In addition, triangle tests were performed at different times during wine aging (among 1 and 9 months) to determine the sensory differences between wines with and without glutathione inactive dry yeast preparations. Descriptive sensory analysis with a trained panel was carried out when sensory differences in the triangle test were noticed. In addition, consumer tests were performed in order to investigate consumers’ acceptability of wines. Results revealed significant sensory differences between control and glutathione inactive dry yeast wines after 9 months of aging. At that time, glutathione inactive dry yeast wines were more intense in fruity aromas (strawberry, banana) and less intense in yeast notes than control wine. The impact of the glutathione inactive dry yeast in the aroma might be the consequence of different effects that these preparations could induce in wine composition: modification of yeast byproducts during fermentation, release of volatile compounds from inactive dry yeast, interaction of wine volatile compounds with yeast macromolecules from inactive dry yeast and a possible antioxidant effect of the glutathione released by the inactive dry yeast preparation on some specific volatile compounds.

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Antecedentes: El potencial alergénico de las proteínas puede alterarse mediante modificaciones fisicoquímicas. El glutatión (GSH) es un agente reductor utilizado como antioxidante en productos alimentarios. Objetivo: Este estudio pretende caracterizar el plegamiento natural de las proteínas de melocotón y cuantificar la alergenicidad del alérgeno mayor del melocotón, Pru p 3, natural y reducido. Métodos: Para ello, se purificó Pru p 3 y se analizó su conformación mediante dicroismo circular (DC). Mediante el análisis con tiol fluorescente, se detectaron las proteínas reducidas en melocotones frescos. Pru p 3 reducido por GSH fue analizado mediante un ensayo in vitro de proliferación de células T e in vivo mediante prueba cutánea. Resultados: Pru p 3 reducido produjo reacciones variables en las pruebas cutáneas de los pacientes alérgicos a melocotón; sin embargo, su estabilidad a la digestión gastrointestinal fue similar a la de la forma natural. La respuesta proliferativa de las células mononucleares de los pacientes alérgicos frente a Pru p 3 reducido mostró una tendencia a ser inferior, mientras que la secreción de citocinas IFN?, IL5 e IL10 fue similar a la producida con la forma natural. La reducción alteró la unión de la IgE a Pru p 3 en un pool de sueros de pacientes alérgicos a melocotón. Conclusin: En conclusión, el glutatión es capaz de reducir Pru p 3, al menos de forma transitoria. En nuestro estudio, la reducción no afectó a la alergenicidad de Pru p 3, de forma que dicho aditivo no parece resolver el riesgo de alergia en pacientes alérgicos a melocotón. Palabras clave: GSH. Pru p 3. Alergia a melocotón. Agente reductor. Unión a IgE.