Merging person-specific bio-markers for predicting oral cancer recurrence through an ontology

One of the major problems related to cancer treatment is its recurrence. Without knowing in advance how likely the cancer will relapse, clinical practice usually recommends adjuvant treatments that have strong side effects. A way to optimize treatments is to predict the recurrence probability by analyzing a set of bio-markers. The NeoMark European project has identified a set of preliminary bio-markers for the case of oral cancer by collecting a large series of data from genomic, imaging, and clinical evidence. This heterogeneous set of data needs a proper representation in order to be stored, computed, and communicated efficiently. Ontologies are often considered the proper mean to integrate biomedical data, for their high level of formality and for the need of interoperable, universally accepted models. This paper presents the NeoMark system and how an ontology has been designed to integrate all its heterogeneous data. The system has been validated in a pilot in which data will populate the ontology and will be made public for further research.

Principios Modernos y Organización de Proyectos

La tesis desvela el origen moderno del modo de afrontar el proyecto de arquitectura mediante métodos de ordenación. Estos procedimientos, fieles a la poética que los respalda, establecen unos principios que anteceden y constituyen la base del método y estos son técnicos, funcionales y sociales. Una cartografía de los principios propuestos por los arquitectos y los teóricos de la arquitectura nos aporta el medio de investigación de la tesis, los libros de arquitecto. La intelectualización y conceptualización que conlleva la arquitectura durante el siglo XX, favorecida por la asociación de los arquitectos, los historiadores y los críticos en encuentros y debates, fomentará la aparición de textos en los que el proyecto de arquitectura se contextualice en su entorno. De esta manera se deja de lado la resolución de un proyecto concreto, mediante la elección entre diversas posibilidades contingentes, para establecer que el acto de proyectar constituye un problema abstracto. Esta postura modifica la resolución del proyecto de arquitectura que ahora se acomete como un caso particular a resolver según los principios y métodos propuestos. Los libros de arquitecto se evidencian como el medio privilegiado para exponer los principios y los métodos de organización de estos, posicionándolos en el ambiente cultural y social. Los principios técnica, función y ciudad que fascinan a los arquitectos desde los años veinte, sufren un proceso de puesta en crisis entre el final de la II Guerra Mundial y la crisis del petróleo del año 1973. A partir de los años setenta pierden su vigencia y ya no deslumbran. Quedan relegados a un principio más, que afecta al proyecto de arquitectura, pero no lo determina. Este desplazamiento en vez de debilitarlos hace que se manifiesten en todo su poder creativo. Las herramientas que explicitan estos principios tales como, la seriación, la modulación, el cambio de escala, los métodos de organización jerarquizados o adaptables, las taxonomías, los diagramas y los relatos, pierden su carga de novedad y de certeza, y su poder metafórico alcanzando la contemporaneidad convertidas en una estructura conceptual sobre la que se organizan los proyectos de arquitectura. ABSTRACT This dissertation reveals the modernist origins of approaching architectural design through organizational methods. These procedures, true to the poetics that back them, establish certain principles that precede and constitute the foundations of the method, and they are technical, functional and social. A map of the principles proposed by architects and architecture theorists provides the means of research of this dissertation; architect’s books. The intellectualization and conceptualization regarding architecture during the 20th century, assisted by the association of architects, historians and critics through conferences and debates, encouraged the advent of texts in which the architectural project is contextualized in its surroundings. In this way, the issue of solving a specific design is set aside by choosing between a diverse set of possible contingencies, establishing that the act of designing constitutes an abstract problem. This stance changed the way the architectural project was carried out by becoming a specific case to be worked out according to the principles and methods proposed. Architect’s books become the privileged means to present the principles and organizational methods of architects, positioning them in cultural and social circles. The principles of technology, functionality and urbanity that had fascinated architects since the 1920s, were put into question between the end of World War II and the 1973 oil crisis. After the 1970s these principles were no longer valid and ceased to amaze. But this displacement, instead of debilitating them, made them appear in their full creative force. The tools that assert these principles, such as serial production, modulation, change of scales, hierarchical or adaptable organizational methods, taxonomies, diagrams and narratives, lose their novel and undisputed content as well as their metaphorical power, reaching us, nowadays, turned into a conceptual structure upon which we organize architectural design.