2 resultados para 5-41

em Universidad Politécnica de Madrid


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Background: One of the main challenges for biomedical research lies in the computer-assisted integrative study of large and increasingly complex combinations of data in order to understand molecular mechanisms. The preservation of the materials and methods of such computational experiments with clear annotations is essential for understanding an experiment, and this is increasingly recognized in the bioinformatics community. Our assumption is that offering means of digital, structured aggregation and annotation of the objects of an experiment will provide necessary meta-data for a scientist to understand and recreate the results of an experiment. To support this we explored a model for the semantic description of a workflow-centric Research Object (RO), where an RO is defined as a resource that aggregates other resources, e.g., datasets, software, spreadsheets, text, etc. We applied this model to a case study where we analysed human metabolite variation by workflows. Results: We present the application of the workflow-centric RO model for our bioinformatics case study. Three workflows were produced following recently defined Best Practices for workflow design. By modelling the experiment as an RO, we were able to automatically query the experiment and answer questions such as “which particular data was input to a particular workflow to test a particular hypothesis?”, and “which particular conclusions were drawn from a particular workflow?”. Conclusions: Applying a workflow-centric RO model to aggregate and annotate the resources used in a bioinformatics experiment, allowed us to retrieve the conclusions of the experiment in the context of the driving hypothesis, the executed workflows and their input data. The RO model is an extendable reference model that can be used by other systems as well.

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En este Proyecto de Construcción se trata el acondicionamiento y mejora de un tramo de la N-III, entre el p.k. 35+000 y su enlace con la A-3, situado en la localidad madrileña de Perales de Tajuña. Esta carretera, que en otra época fue la principal vía de comunicación entre la capital de España y la costa levantina, ha visto reducida su importancia hasta convertirse en la práctica en una carretera de orden local. Se han estudiado, por tanto, distintas alternativas para adaptar las características de la vía a la demanda que actualmente presenta, prestando atención a todos los condicionantes que presenta, y se ha desarrollado la solución que se ha considerado más adecuada