1 resultado para disease modifying antirheumatic drug
em Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP)
Filtro por publicador
- Repository Napier (1)
- University of Cagliari UniCA Eprints (1)
- ABACUS. Repositorio de Producción Científica - Universidad Europea (1)
- Aberdeen University (5)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (8)
- Applied Math and Science Education Repository - Washington - USA (1)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (5)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (3)
- Aston University Research Archive (23)
- B-Digital - Universidade Fernando Pessoa - Portugal (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (11)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (4)
- Bioline International (2)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (106)
- Brock University, Canada (2)
- CaltechTHESIS (1)
- Cambridge University Engineering Department Publications Database (2)
- CentAUR: Central Archive University of Reading - UK (18)
- Centro Hospitalar do Porto (1)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (1)
- Cochin University of Science & Technology (CUSAT), India (1)
- Coffee Science - Universidade Federal de Lavras (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (5)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (1)
- Dalarna University College Electronic Archive (3)
- Deakin Research Online - Australia (35)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (2)
- Digital Commons at Florida International University (3)
- Digital Knowledge Repository of Central Drug Research Institute (1)
- DigitalCommons@The Texas Medical Center (10)
- Duke University (9)
- Düsseldorfer Dokumenten- und Publikationsservice (1)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (1)
- Glasgow Theses Service (1)
- Helda - Digital Repository of University of Helsinki (17)
- Indian Institute of Science - Bangalore - Índia (7)
- Instituto Politécnico do Porto, Portugal (1)
- National Center for Biotechnology Information - NCBI (10)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (62)
- Queensland University of Technology - ePrints Archive (377)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (1)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (4)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (69)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (2)
- Scientific Open-access Literature Archive and Repository (1)
- Universidad del Rosario, Colombia (9)
- Universidad Politécnica de Madrid (1)
- Universidade Complutense de Madrid (1)
- Universidade de Lisboa - Repositório Aberto (5)
- Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) (1)
- Universidade Federal do Pará (1)
- Universita di Parma (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (11)
- Université de Montréal (1)
- Université de Montréal, Canada (10)
- University of Michigan (4)
- University of Queensland eSpace - Australia (22)
- University of Washington (1)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the inclusion complex between NFOH and HP-beta-CD. The rate of NFOH release decreases after complexation and thermodynamic parameters from the solubility isotherm studies revealed that a stable complex is formed (deltaGº= 1.7 kJ/mol). This study focuses on the physico-chemical characterization of a drug-delivery formulation that comes out as a potentially new therapeutic option for Chagas disease treatment.