MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation

Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) is a simple system centred around the patient which was devised to fill many of these gaps using Information and Communications Technology (ICT) tools and a clinical decision support system (CDSS) based on the most widely used guideline in allergic rhinitis and its asthma comorbidity (ARIA 2015 revision). It is one of the implementation systems of Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA). Three tools are used for the electronic monitoring of allergic diseases: a cell phone-based daily visual analogue scale (VAS) assessment of disease control, CARAT (Control of Allergic Rhinitis and Asthma Test) and e-Allergy screening (premedical system of early diagnosis of allergy and asthma based on online tools). These tools are combined with a clinical decision support system (CDSS) and are available in many languages. An e-CRF and an e-learning tool complete MASK. MASK is flexible and other tools can be added. It appears to be an advanced, global and integrated ICT answer for many unmet needs in allergic diseases which will improve policies and standards.

ESMO consensus guidelines for the management of patients with metastatic colorectal cancer

Colorectal cancer (CRC) is one of the most common malignancies in Western countries. Over the last 20 years, and the last decade in particular, the clinical outcome for patients with metastatic CRC (mCRC) has improved greatly due not only to an increase in the number of patients being referred for and undergoing surgical resection of their localised metastatic disease but also to a more strategic approach to the delivery of systemic therapy and an expansion in the use of ablative techniques. This reflects the increase in the number of patients that are being managed within a multidisciplinary team environment and specialist cancer centres, and the emergence over the same time period not only of improved imaging techniques but also prognostic and predictive molecular markers. Treatment decisions for patients with mCRC must be evidence-based. Thus, these ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.

Do hereditary syndrome-related gynecologic cancers have any specific features?

Hereditary syndromes are responsible for 10 % of gynaecologic cancers, among which hereditary breastovarian cancer and hereditary non-polyposis colon cancer syndromes, known as HBOC and Lynch syndromes respectively, present the highest relative risk. The latter predisposes to endometrial cancer and both contribute to ovarian cancer. Cowden syndrome-related endometrial cancer and the increased risk of ovarian, uterine and cervical cancers associated with Peutz-Jeghers syndrome, are also demonstrated, while Li-Fraumeni syndrome patients are prone to develop ovarian and endometrial cancers. Despite these syndromes’ susceptibility to gynaecologic cancers being consensual, it is still not clear whether these tumours have any epidemiologic, clinical, pathologic or imaging specific features that could allow any of the intervening physicians to raise suspicion of a hereditary syndrome in patients without known genetic risk. Moreover, controversy exists regarding both screening and surveillance schemes. Our literature review provides an updated perspective on the evidence-based specific features of tumours related to each of these syndromes as well as on the most accepted screening and surveillance guidelines. In addition, some illustrative cases are presented.

Visit Cabo Verde

A indústria turística tem-se focado na diversificação, de forma contínua, tornando-se um dos motores fundamentais para o progresso dos setores económicos de um país. Para tal, o desenvolvimento de um Produto Turístico de sucesso que visa oferecer ao público-alvo uma experiência memorável para satisfazer o seu desejo é essencial para que este consumidor venha a visitar um determinado destino. A nova era digital transformou a estratégia de marketing das empresas e esta nova conjuntura tem vindo a contribuir para o crescimento exponencial e para o desenvolvimento das técnicas e ferramentas que permitem promover a comunicação entre a empresa/marca e o consumidor, aspeto em que o marketing digital tem desempenhado um papel importante. Em tempos de valorização da experiência turística, o setor turístico de Cabo Verde pouco tem explorado e não tem tirado grande partido do marketing digital para dar a conhecer as potencialidades e as maravilhas do destino enquanto produto turístico, que ainda tem muito por descobrir por parte dos consumidores nacionais e internacionais. Como objetivos deste plano de comunicação Visit Cabo Verde pretende-se aumentar a notoriedade da marca Cabo Verde e captar novos turistas através da promoção de 4 ilhas: Santiago, São Vicente, Santo Antão e Boavista dividindo-as em 3 (três) subprodutos - cultura, natureza e praia. Com a realização deste projeto prevê-se que Cabo Verde atinja o público-alvo definido através da conceção das campanhas relevantes para os potenciais turistas e aumentar o fluxo dos turistas no arquipélago. As limitações deste plano de comunicação incidem sobre a variável produto que não é controlável, procurando este plano uma linha de orientação para a variável comunicação.