1 resultado para knowledge work
em Instituto Nacional de Saúde de Portugal
Filtro por publicador
- JISC Information Environment Repository (3)
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- Academic Archive On-line (Jönköping University; Sweden) (2)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (4)
- Andina Digital - Repositorio UASB-Digital - Universidade Andina Simón Bolívar (1)
- Aquatic Commons (4)
- Archive of European Integration (3)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (1)
- Aston University Research Archive (57)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (10)
- Bioline International (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (14)
- Boston University Digital Common (1)
- Brock University, Canada (1)
- Bulgarian Digital Mathematics Library at IMI-BAS (10)
- Cambridge University Engineering Department Publications Database (2)
- CentAUR: Central Archive University of Reading - UK (30)
- Clark Digital Commons--knowledge; creativity; research; and innovation of Clark University (1)
- Cochin University of Science & Technology (CUSAT), India (1)
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- Instituto Nacional de Saúde de Portugal (1)
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- Instituto Superior de Psicologia Aplicada - Lisboa (2)
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- Repositório Aberto da Universidade Aberta de Portugal (1)
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- Repositório Científico da Escola Superior de Enfermagem de Coimbra (3)
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- Repositório digital da Fundação Getúlio Vargas - FGV (1)
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- Research Open Access Repository of the University of East London. (2)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (3)
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- Universitätsbibliothek Kassel, Universität Kassel, Germany (3)
- Université de Montréal, Canada (3)
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- University of Connecticut - USA (1)
- University of Michigan (17)
- University of Queensland eSpace - Australia (13)
- University of Washington (13)
- WestminsterResearch - UK (7)
- Worcester Research and Publications - Worcester Research and Publications - UK (2)
Resumo:
Due to their unique physicochemical properties, including superparamagnetism, iron oxide nanoparticles (ION) have a number of interesting applications, especially in the biomedical field, that make them one of the most fascinating nanomaterials. They are used as contrast agents for magnetic resonance imaging, in targeted drug delivery, and for induced hyperthermia cancer treatments. Together with these valuable uses, concerns regarding the onset of unexpected adverse health effects following exposure have been also raised. Nevertheless, despite the numerous ION purposes being explored, currently available information on their potential toxicity is still scarce and controversial data have been reported. Although ION have traditionally been considered as biocompatible - mainly on the basis of viability tests results - influence of nanoparticle surface coating, size, or dose, and of other experimental factors such as treatment time or cell type, has been demonstrated to be important for ION in vitro toxicity manifestation. In vivo studies have shown distribution of ION to different tissues and organs, including brain after passing the blood-brain barrier; nevertheless results from acute toxicity, genotoxicity, immunotoxicity, neurotoxicity and reproductive toxicity investigations in different animal models do not provide a clear overview on ION safety yet, and epidemiological studies are almost inexistent. Much work has still to be done to fully understand how these nanomaterials interact with cellular systems and what, if any, potential adverse health consequences can derive from ION exposure.