1 resultado para Z Refinement
em Instituto Gulbenkian de Ciência
Filtro por publicador
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (4)
- Adam Mickiewicz University Repository (3)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (5)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (6)
- Applied Math and Science Education Repository - Washington - USA (1)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (5)
- Archive of European Integration (13)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (15)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (31)
- Biblioteca Valenciana Digital - Ministerio de Educación, Cultura y Deporte - Valencia - Espanha (1)
- Biblioteca Virtual del Sistema Sanitario Público de Andalucía (BV-SSPA), Junta de Andalucía. Consejería de Salud y Bienestar Social, Spain (1)
- Bibloteca do Senado Federal do Brasil (20)
- Biodiversity Heritage Library, United States (3)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (70)
- Brock University, Canada (4)
- CentAUR: Central Archive University of Reading - UK (29)
- Cochin University of Science & Technology (CUSAT), India (9)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (1)
- Consorci de Serveis Universitaris de Catalunya (CSUC), Spain (12)
- CUNY Academic Works (1)
- Department of Computer Science E-Repository - King's College London, Strand, London (2)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons at Florida International University (1)
- DigitalCommons - The University of Maine Research (1)
- DigitalCommons@The Texas Medical Center (2)
- DigitalCommons@University of Nebraska - Lincoln (1)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (118)
- Diposit Digital de la UB - Universidade de Barcelona (2)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (49)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (64)
- Georgian Library Association, Georgia (5)
- Harvard University (35)
- Instituto Gulbenkian de Ciência (1)
- Instituto Politécnico do Porto, Portugal (2)
- Iowa Publications Online (IPO) - State Library, State of Iowa (Iowa), United States (2)
- Livre Saber - Repositório Digital de Materiais Didáticos - SEaD-UFSCar (2)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (2)
- Martin Luther Universitat Halle Wittenberg, Germany (3)
- Memoria Académica - FaHCE, UNLP - Argentina (2)
- Ministerio de Cultura, Spain (13)
- National Center for Biotechnology Information - NCBI (18)
- Portal do Conhecimento - Ministerio do Ensino Superior Ciencia e Inovacao, Cape Verde (4)
- Publishing Network for Geoscientific & Environmental Data (63)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (2)
- Repositório da Produção Científica e Intelectual da Unicamp (1)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (1)
- Repositorio Institucional da UFLA (RIUFLA) (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (151)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (7)
- School of Medicine, Washington University, United States (1)
- Scielo Saúde Pública - SP (11)
- Universidad Autónoma de Nuevo León, Mexico (2)
- Universidad de Alicante (2)
- Universidad del Rosario, Colombia (1)
- Universidad Politécnica de Madrid (9)
- Universidade Complutense de Madrid (12)
- Universidade do Minho (12)
- Universidade Federal do Pará (3)
- Universidade Federal do Rio Grande do Norte (UFRN) (2)
- Universitat de Girona, Spain (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (7)
- Université de Lausanne, Switzerland (15)
- Université de Montréal (1)
- Université de Montréal, Canada (5)
- University of Michigan (51)
- University of Queensland eSpace - Australia (32)
Resumo:
In vertebrate species, the innate immune system down-regulates protein translation in response to viral infection through the action of the double-stranded RNA (dsRNA)-activated protein kinase (PKR). In some teleost species another protein kinase, Z-DNA-dependent protein kinase (PKZ), plays a similar role but instead of dsRNA binding domains, PKZ has Zα domains. These domains recognize the left-handed conformer of dsDNA and dsRNA known as Z-DNA/Z-RNA. Cyprinid herpesvirus 3 infects common and koi carp, which have PKZ, and encodes the ORF112 protein that itself bears a Zα domain, a putative competitive inhibitor of PKZ. Here we present the crystal structure of ORF112-Zα in complex with an 18-bp CpG DNA repeat, at 1.5 Å. We demonstrate that the bound DNA is in the left-handed conformation and identify key interactions for the specificity of ORF112. Localization of ORF112 protein in stress granules induced in Cyprinid herpesvirus 3-infected fish cells suggests a functional behavior similar to that of Zα domains of the interferon-regulated, nucleic acid surveillance proteins ADAR1 and DAI.