1 resultado para Level 4 Evidence
em Instituto Gulbenkian de Ciência
Filtro por publicador
- JISC Information Environment Repository (1)
- Academic Archive On-line (Stockholm University; Sweden) (1)
- Academic Research Repository at Institute of Developing Economies (13)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (2)
- Aquatic Commons (5)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (2)
- Archive of European Integration (7)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (1)
- Aston University Research Archive (17)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (22)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (10)
- Bioline International (2)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (95)
- Brock University, Canada (1)
- Cambridge University Engineering Department Publications Database (4)
- CentAUR: Central Archive University of Reading - UK (26)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (6)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (1)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (1)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (36)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (4)
- Digital Commons at Florida International University (3)
- Digital Peer Publishing (1)
- DigitalCommons@The Texas Medical Center (7)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (6)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (13)
- FUNDAJ - Fundação Joaquim Nabuco (2)
- Helda - Digital Repository of University of Helsinki (21)
- Hospitais da Universidade de Coimbra (1)
- Indian Institute of Science - Bangalore - Índia (33)
- Instituto Gulbenkian de Ciência (1)
- Instituto Politécnico de Viseu (2)
- Instituto Politécnico do Porto, Portugal (1)
- Ministerio de Cultura, Spain (4)
- National Center for Biotechnology Information - NCBI (9)
- Nottingham eTheses (1)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (3)
- Portal de Revistas Científicas Complutenses - Espanha (2)
- Publishing Network for Geoscientific & Environmental Data (26)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (43)
- Queensland University of Technology - ePrints Archive (337)
- Repositório digital da Fundação Getúlio Vargas - FGV (4)
- Repositório Institucional da Universidade Federal de São Paulo - UNIFESP (1)
- Repositório Institucional da Universidade Federal do Rio Grande - FURG (1)
- Repositório Institucional dos Hospitais da Universidade Coimbra (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (29)
- Research Open Access Repository of the University of East London. (2)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (1)
- Universidad de Alicante (2)
- Universidad del Rosario, Colombia (23)
- Universidad Politécnica de Madrid (6)
- Universidade Complutense de Madrid (2)
- Universidade Federal do Pará (1)
- Universidade Federal do Rio Grande do Norte (UFRN) (2)
- Université de Lausanne, Switzerland (7)
- Université de Montréal (2)
- Université de Montréal, Canada (7)
- University of Connecticut - USA (2)
- University of Michigan (14)
- University of Queensland eSpace - Australia (12)
- University of Southampton, United Kingdom (1)
- WestminsterResearch - UK (1)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
Sister chromatid cohesion, mediated by the cohesin complex, is essential for faithful mitosis. Nevertheless, evidence suggests that the surveillance mechanism that governs mitotic fidelity, the spindle assembly checkpoint (SAC), is not robust enough to halt cell division when cohesion loss occurs prematurely. The mechanism behind this poor response is not properly understood. Using developing Drosophila brains, we show that full sister chromatid separation elicits a weak checkpoint response resulting in abnormal mitotic exit after a short delay. Quantitative live-cell imaging approaches combined with mathematical modeling indicate that weak SAC activation upon cohesion loss is caused by weak signal generation. This is further attenuated by several feedback loops in the mitotic signaling network. We propose that multiple feedback loops involving cyclin-dependent kinase 1 (Cdk1) gradually impair error-correction efficiency and accelerate mitotic exit upon premature loss of cohesion. Our findings explain how cohesion defects may escape SAC surveillance.