1 resultado para Immunization promotion
em Instituto Gulbenkian de Ciência
Filtro por publicador
- JISC Information Environment Repository (4)
- Aberdeen University (4)
- Abertay Research Collections - Abertay University’s repository (1)
- Academic Research Repository at Institute of Developing Economies (4)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (5)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (1)
- Aquatic Commons (8)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (1)
- Archive of European Integration (63)
- Aston University Research Archive (16)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (11)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (3)
- Bioline International (7)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (40)
- Brock University, Canada (5)
- Bulgarian Digital Mathematics Library at IMI-BAS (2)
- Cambridge University Engineering Department Publications Database (3)
- CentAUR: Central Archive University of Reading - UK (20)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (18)
- Cochin University of Science & Technology (CUSAT), India (2)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (44)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (172)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (3)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons at Florida International University (5)
- Digital Repository at Iowa State University (1)
- DigitalCommons@The Texas Medical Center (24)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (3)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (3)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (1)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (2)
- Harvard University (1)
- Helda - Digital Repository of University of Helsinki (1)
- Indian Institute of Science - Bangalore - Índia (11)
- Institute of Public Health in Ireland, Ireland (2)
- Instituto Gulbenkian de Ciência (1)
- Instituto Nacional de Saúde de Portugal (3)
- Instituto Politécnico de Viseu (1)
- Instituto Superior de Psicologia Aplicada - Lisboa (1)
- Iowa Publications Online (IPO) - State Library, State of Iowa (Iowa), United States (3)
- Memoria Académica - FaHCE, UNLP - Argentina (3)
- Ministerio de Cultura, Spain (1)
- National Center for Biotechnology Information - NCBI (31)
- Nottingham eTheses (2)
- Portal de Revistas Científicas Complutenses - Espanha (1)
- Publishing Network for Geoscientific & Environmental Data (3)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (59)
- Queensland University of Technology - ePrints Archive (93)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- Repositorio Académico de la Universidad Nacional de Costa Rica (2)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (1)
- Repositório Científico da Universidade de Évora - Portugal (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (3)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (33)
- Repositorio Institucional UNISALLE - Colombia (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (3)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (7)
- School of Medicine, Washington University, United States (5)
- South Carolina State Documents Depository (2)
- Universidad Autónoma de Nuevo León, Mexico (1)
- Universidad de Alicante (2)
- Universidad del Rosario, Colombia (6)
- Universidad Politécnica de Madrid (4)
- Universidade de Lisboa - Repositório Aberto (2)
- Universidade Federal do Rio Grande do Norte (UFRN) (1)
- Universidade Metodista de São Paulo (1)
- Universita di Parma (1)
- Universitat de Girona, Spain (1)
- Université de Lausanne, Switzerland (5)
- Université de Montréal (6)
- Université de Montréal, Canada (34)
- Université Laval Mémoires et thèses électroniques (3)
- University of Canberra Research Repository - Australia (2)
- University of Connecticut - USA (5)
- University of Michigan (75)
- University of Queensland eSpace - Australia (43)
- University of Southampton, United Kingdom (2)
- University of Washington (2)
- WestminsterResearch - UK (1)
Resumo:
Susceptibility to autoimmune diseases results from the encounter of a complex and long evolved genetic context with a no less complex and changing environment. Major actors in maintaining health are regulatory T cells (Treg) that primarily dampen a large subset of autoreactive lymphocytes escaping thymic negative selection. Here, we directly asked whether Treg participate in defining susceptibility and resistance to Experimental Autoimmune Prostatitis (EAP). We analyzed three common laboratory strains of mice presenting with different susceptibility to autoimmune prostatitis upon immunization with prostate proteins. The NOD, the C57BL/6 and the BALB/c mice that can be classified along a disease score ranging from severe, mild and to undetectable, respectively. Upon mild and transient depletion of Treg at the induction phase of EAP, each model showed an increment along this score, most remarkably with the BALB/c mice switching from a resistant to a susceptible phenotype. We further show that disease associates with the upregulation of CXCR3 expression on effector T cells, a process requiring IFNγ. Together with recent advances on environmental factors affecting Treg, these findings provide a likely cellular and molecular explanation to the recent rise in autoimmune diseases incidence.