1 resultado para INVERSION ASYMMETRY
em Instituto Gulbenkian de Ciência
Filtro por publicador
- Aberdeen University (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (10)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (1)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (5)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (3)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (5)
- Aston University Research Archive (9)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (8)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (7)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (43)
- Brock University, Canada (1)
- Bulgarian Digital Mathematics Library at IMI-BAS (3)
- CaltechTHESIS (3)
- Cambridge University Engineering Department Publications Database (31)
- CentAUR: Central Archive University of Reading - UK (44)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (88)
- Coffee Science - Universidade Federal de Lavras (1)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (3)
- CORA - Cork Open Research Archive - University College Cork - Ireland (3)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (1)
- CUNY Academic Works (1)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (29)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (10)
- Digital Commons - Michigan Tech (4)
- Digital Commons at Florida International University (2)
- Digital Knowledge Repository of Central Drug Research Institute (1)
- Digital Peer Publishing (1)
- DigitalCommons - The University of Maine Research (1)
- DigitalCommons@The Texas Medical Center (3)
- Duke University (4)
- Earth Simulator Research Results Repository (1)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (2)
- FUNDAJ - Fundação Joaquim Nabuco (1)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (2)
- Helda - Digital Repository of University of Helsinki (50)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (284)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (6)
- Instituto Gulbenkian de Ciência (1)
- Instituto Politécnico do Porto, Portugal (1)
- National Center for Biotechnology Information - NCBI (10)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (5)
- Publishing Network for Geoscientific & Environmental Data (4)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (30)
- Queensland University of Technology - ePrints Archive (115)
- Repositório Científico da Universidade de Évora - Portugal (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (5)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (58)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (3)
- Universidad Politécnica de Madrid (5)
- Universidade Complutense de Madrid (2)
- Universidade de Lisboa - Repositório Aberto (2)
- Universidade Federal do Pará (3)
- Universitat de Girona, Spain (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (2)
- Université de Lausanne, Switzerland (6)
- Université de Montréal (1)
- Université de Montréal, Canada (14)
- University of Canberra Research Repository - Australia (1)
- University of Connecticut - USA (4)
- University of Michigan (7)
- University of Queensland eSpace - Australia (12)
- University of Washington (1)
- WestminsterResearch - UK (2)
Resumo:
A polymorphic inversion that lies on chromosome 17q21 comprises two major haplotype families (H1 and H2) that not only differ in orientation but also in copy-number. Although the processes driving the spread of the inversion-associated lineage (H2) in humans remain unclear, a selective advantage has been proposed for one of its subtypes. Here, we genotyped a large panel of individuals from previously overlooked populations using a custom array with a unique panel of H2-specific single nucleotide polymorphisms and found a patchy distribution of H2 haplotypes in Africa, with North Africans displaying a higher frequency of inverted subtypes, when compared with Sub-Saharan groups. Interestingly, North African H2s were found to be closer to "non-African" chromosomes further supporting that these populations may have diverged more recently from groups outside Africa. Our results uncovered higher diversity within the H2 family than previously described, weakening the hypothesis of a strong selective sweep on all inverted chromosomes and suggesting a rather complex evolutionary history at this locus.