1 resultado para Animals, Newborn
em Instituto Gulbenkian de Ciência
Filtro por publicador
- Aberystwyth University Repository - Reino Unido (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (3)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (7)
- Aquatic Commons (17)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (1)
- Archive of European Integration (52)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (4)
- B-Digital - Universidade Fernando Pessoa - Portugal (1)
- Biblioteca de Teses e Dissertações da USP (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (22)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (7)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (2)
- Biodiversity Heritage Library, United States (21)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (78)
- Brock University, Canada (7)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- CaltechTHESIS (1)
- Cambridge University Engineering Department Publications Database (1)
- CentAUR: Central Archive University of Reading - UK (43)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (8)
- Cochin University of Science & Technology (CUSAT), India (3)
- CORA - Cork Open Research Archive - University College Cork - Ireland (2)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (64)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (2)
- Digital Archives@Colby (1)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Repository at Iowa State University (1)
- DigitalCommons@The Texas Medical Center (6)
- DigitalCommons@University of Nebraska - Lincoln (4)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (6)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (9)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (1)
- Harvard University (1)
- Helda - Digital Repository of University of Helsinki (11)
- Indian Institute of Science - Bangalore - Índia (12)
- Instituto Gulbenkian de Ciência (1)
- Ministerio de Cultura, Spain (54)
- National Center for Biotechnology Information - NCBI (30)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (31)
- Publishing Network for Geoscientific & Environmental Data (14)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (51)
- Queensland University of Technology - ePrints Archive (38)
- RepoCLACAI - Consorcio Latinoamericano Contra el Aborto Inseguro (1)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (161)
- Research Open Access Repository of the University of East London. (2)
- School of Medicine, Washington University, United States (8)
- Universidad Autónoma de Nuevo León, Mexico (1)
- Universidad de Alicante (1)
- Universidad Politécnica de Madrid (2)
- Universidade de Lisboa - Repositório Aberto (2)
- Universidade Federal do Pará (9)
- Universidade Federal do Rio Grande do Norte (UFRN) (2)
- Universita di Parma (2)
- Universitat de Girona, Spain (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (3)
- Université de Lausanne, Switzerland (17)
- Université de Montréal (1)
- Université de Montréal, Canada (5)
- University of Connecticut - USA (2)
- University of Michigan (141)
- University of Queensland eSpace - Australia (2)
- University of Southampton, United Kingdom (2)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
The vertebrate body is made by progressive addition of new tissue from progenitors at the posterior embryonic end. Axial extension involves different mechanisms that produce internal organs in the trunk but not in the tail. We show that Gdf11 signaling is a major coordinator of the trunk-to-tail transition. Without Gdf11 signaling, the switch from trunk to tail is significantly delayed, and its premature activation brings the hindlimbs and cloaca next to the forelimbs, leaving extremely short trunks. Gdf11 activity includes activation of Isl1 to promote formation of the hindlimbs and cloaca-associated mesoderm as the most posterior derivatives of lateral mesoderm progenitors. Gdf11 also coordinates reallocation of bipotent neuromesodermal progenitors from the anterior primitive streak to the tail bud, in part by reducing the retinoic acid available to the progenitors. Our findings provide a perspective to understand the evolution of the vertebrate body plan.