Evaluación del desempeño pronóstico de dos puntajes de predicción de mortalidad a siete días en pacientes adultos oncológicos críticamente enfermos admitidos a una unidad de cuidados intensivos en Bogotá
Contribuinte(s) |
Hernández Herrera, Gilma |
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Data(s) |
20/09/2016
31/12/1969
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Resumo |
Introducción Los sistemas de puntuación para predicción se han desarrollado para medir la severidad de la enfermedad y el pronóstico de los pacientes en la unidad de cuidados intensivos. Estas medidas son útiles para la toma de decisiones clínicas, la estandarización de la investigación, y la comparación de la calidad de la atención al paciente crítico. Materiales y métodos Estudio de tipo observacional analítico de cohorte en el que reviso las historias clínicas de 283 pacientes oncológicos admitidos a la unidad de cuidados intensivos (UCI) durante enero de 2014 a enero de 2016 y a quienes se les estimo la probabilidad de mortalidad con los puntajes pronósticos APACHE IV y MPM II, se realizó regresión logística con las variables predictoras con las que se derivaron cada uno de los modelos es sus estudios originales y se determinó la calibración, la discriminación y se calcularon los criterios de información Akaike AIC y Bayesiano BIC. Resultados En la evaluación de desempeño de los puntajes pronósticos APACHE IV mostro mayor capacidad de predicción (AUC = 0,95) en comparación con MPM II (AUC = 0,78), los dos modelos mostraron calibración adecuada con estadístico de Hosmer y Lemeshow para APACHE IV (p = 0,39) y para MPM II (p = 0,99). El ∆ BIC es de 2,9 que muestra evidencia positiva en contra de APACHE IV. Se reporta el estadístico AIC siendo menor para APACHE IV lo que indica que es el modelo con mejor ajuste a los datos. Conclusiones APACHE IV tiene un buen desempeño en la predicción de mortalidad de pacientes críticamente enfermos, incluyendo pacientes oncológicos. Por lo tanto se trata de una herramienta útil para el clínico en su labor diaria, al permitirle distinguir los pacientes con alta probabilidad de mortalidad. Introduction Scoring systems for prediction have been developed to measure the severity of the disease and the prognosis of patients in the intensive care unit. These measures are useful for clinical decision-making, standardization of research and comparing the quality of care to critically ill patients. Materials and methods Study of analytical observational cohort who reviewed the medical records of 283 cancer patients admitted to the intensive care unit during January 2014 to January 2016 and which were calculated the probability of mortality APACHE IV and MPM II, logistic regression was performed with the predictor variables that were derived each of the models is their original studies and calibration is determined, discrimination and Akaike information criteria AIC and BIC Bayesian were calculated. Results In assessing prognostic performance APACHE IV scores showed greater capacity for discrimination (AUC = 0.95) compared with MPM II (AUC = 0.78), the two models showed adequate calibration Hosmer and Lemeshow statistic for APACHE IV (p = 0.39) and MPM II (p = 0.99) Conclusions APACHE IV has a good performance in predicting mortality of critically ill patients, including cancer patients. Therefore it is a useful tool for clinicians in their daily work by allowing you to distinguish patients with high probability of mortality. |
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application/pdf |
Identificador | |
Idioma(s) |
spa |
Publicador |
Facultad de medicina |
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info:eu-repo/semantics/embargoedAccess |
Fonte |
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Palavras-Chave | #QZ 206 #Mortalidad hospitalaria -- predicciones #Neoplasias -- análisis #Pronosctic score #Critical care #Cancer #Mortality |
Tipo |
info:eu-repo/semantics/masterThesis info:eu-repo/semantics/acceptedVersion |