Factores de riesgo asociados al desarrollo de bacteriemia en pacientes adultos cirróticos hospitalizados
Contribuinte(s) |
Castañeda, Ximena |
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Data(s) |
01/08/2016
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Resumo |
Introducción: La Bacteriemia en pacientes cirróticos es una causa importante de morbimortalidad, en gran parte favorecida por la especial vulnerabilidad de esta población ante procesos infecciosos. El objetivo fue determinar los factores asociados al desarrollo de bacteriemia primaria y secundaria en pacientes con Cirrosis, hospitalizados en la Fundación Cardioinfantil – Instituto de Cardiología entre 01 enero de 2010 y 31 enero de 2016. Materiales y Métodos: Estudio de casos y controles en pacientes mayores de 18 años con cirrosis hepática conocida o confirmada durante la hospitalización. Se realizó un análisis descriptivo, un análisis bivariado para determinar las diferencias entre los casos y los controles con respecto a las variables independientes un análisis de asociación mediante un modelo de regresión logística no condicional con variable dependiente bacteriemia. Los resultados se expresan en odds ratios con intervalos de confianza al 95%. Resultados: Las condiciones asociadas a bacteriemia como factores de riesgo fueron: Enfermedad renal crónica OR 9,1 (IC 95% 2,4-34), Escala Meld > 10 puntos OR 4,0 (IC 95% 2,-34), Infección previa OR 7,2 (IC 95% 2,1-24), presencia de catéter central OR 12,0 (IC 95% 1,8-80), presencia de sonda vesical OR 21,1 (IC 95% 1,6-276), estudio endoscópico OR 3,9 (IC 95% 1,1-14). Discusión: Factores relacionados con las condiciones clínicas del paciente evaluadas por las escalas Meld y Child-Pugh, el antecedente de infección previa y la presencia de dispositivos para monitorear el estado del paciente aumentan el riesgo de bacteriemia en pacientes hospitalizados con cirrosis. Introduction: bacteremia in cirrhotic patients is an important cause of morbidity and mortality, favored by the particular vulnerability of this population to infectious diseases. The objective was to determine the factors associated with the development of primary and secondary bacteremia in patients with cirrhosis hospitalized in the Fundación Cardioinfantil - Instituto de Cardiología between January 1, 2010 and January 31, 2016. Materials and Methods: Case-control study in patients over 18 years with liver cirrhosis known or confirmed during hospitalization. A descriptive analysis was performed, bivariate analysis was done to determine differences between cases and controls with respect to the independent variables, association analysis was done using a model of unconditional logistic regression with bacteremia as a dependent variable. The results are expressed in odds ratios with confidence intervals at 95%. Results: Factors associated with bacteremia as risk factors were: chronic kidney disease OR 9.1 (95% CI 2.4 to 34), Meld score > 10 points OR 4.0 (95% CI 2 -34) previous infection OR 7.2 (95% CI 2.1 to 24), presence of central catheter OR 12.0 (95% CI 1.8 to 80), presence of urinary catheter OR 21.1 (95% CI 1 6-276), endoscopy OR 3.9 (95% CI 1.1 to 14). Discussion: Factors related to the patient's clinical condition assessed by the Child-Pugh and Meld scores, history of previous infection and the presence of devices to monitor the patient's condition increase the risk of bacteremia in hospitalized patients with cirrhosis. |
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application/pdf |
Identificador | |
Idioma(s) |
spa |
Publicador |
Facultad de Medicina |
Direitos |
info:eu-repo/semantics/openAccess |
Fonte |
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Palavras-Chave | #Medicina interna #616 #Medicina inerna #Epidemiología #Bacteriemia #Infectología #Liver Cirrhosis #bacteremia #bloodstream infections #epidemiology #Kang CI, Song JH, Chung DR, Peck KR, Yeom JS, Ki HK, et al. Liver cirrhosis as a risk factor for mortality in a national cohort of patients with bacteremia. J Infect. Elsevier Ltd; 2011;63(5):336–43. |
Tipo |
info:eu-repo/semantics/bachelorThesis info:eu-repo/semantics/acceptedVersion |