Transmissible cancers in an evolutionary context
Data(s) |
01/01/2016
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Resumo |
Cancer is an evolutionary and ecological process in which complex interactions between tumour cells and their environment share many similarities with organismal evolution. Tumour cells with highest adaptive potential have a selective advantage over less fit cells. Naturally occurring transmissible cancers provide an ideal model system for investigating the evolutionary arms race between cancer cells and their surrounding micro-environment and macro-environment. However, the evolutionary landscapes in which contagious cancers reside have not been subjected to comprehensive investigation. Here, we provide a multifocal analysis of transmissible tumour progression and discuss the selection forces that shape it. We demonstrate that transmissiblecancers adapt to both their micro-environment and macroenvironment,and evolutionary theories applied to organisms are also relevant to these unique diseases. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Wiley-Blackwell |
Relação |
http://dro.deakin.edu.au/eserv/DU:30090271/ujvari-transmissiblecancers-2016.pdf http://www.dx.doi.org/10.1002/icl3.1020 |
Direitos |
2015, The Authors |
Palavras-Chave | #cancer evolution #canine transmissible venereal tumour #clam leukaemia #micro-environment #Tasmanian devil facial tumour disease |
Tipo |
Journal Article |