Complications of pneumococcal bacteremia after 13-valent conjugate vaccine withdrawal


Autoria(s): Tagarro, Alfredo; Bote, Patricia; Sánchez, Aida; Otheo, Enrique; Sanz, Juan Carlos; Sanz Rosa, David
Data(s)

22/07/2016

22/07/2016

2016

Resumo

In the Region of Madrid, universal immunization with the 13-serotypes pneumococcal conjugate vaccine (PCV13) started in May 2010. In July 2012, public funding ceased. Vaccination coverage decreased from >95% to 82% in 2013 and to 67% in 2014. Our aim was to investigate the impact of PCV13 withdrawal from Madrid Region's universal immunization program on the incidence of complicated pneumococcal bacteremia. We performed a multi-center retrospective cohort study, from 2009 to 2014. Participants were children aged <14 years with Streptococcus pneumoniae bacteremia. Complications were defined as any condition requiring intensive care or surgery. Sequelae were conditions lasting ≥90 days. A total of 168 patients were recruited. One-fourth of both immunized and non-immunized patients had complications. Global complications increased after PCV13 withdrawal. A total of 28% of PCV13 serotypes presented complications. Complications due to PCV13 serotypes did not increase after July 2012. No-PCV13 serotypes increased progressively from 2009 on, and 23% presented complications. A significant risk of complications was found for patients with meningitis, empyema, C-reactive protein >100 mg/L, and serotype 1. A multivariate analysis indicated that complications were associated with meningitis and hospital admission after July 2012. Sequelae were significantly associated with children <2 years of age, meningitis and no-PCV13 serotypes. The incidence of complications due to PCV13 serotypes did not increase two years after PCV13 withdrawal. Nevertheless, all-serotypes complications increased. The likely cause was that no-PCV13 serotypes (associated with meningitis) are on the rise.

SIN FINANCIACIÓN

2.587 JCR (2015) Q1, 22/120 Pediatrics; Q2, 38/83 Infectious Diseases; Q3, 84/150 Immunology

UEM

Identificador

Tagarro, A., Bote, P., Sánchez, A., Otheo, E., Sanz, J. C., Sanz-Rosa, D. (2016). Complications of pneumococcal bacteremia after 13-valent conjugate vaccine withdrawal. Pediatric Infectious Disease Journal, 35(12), 1281-1287. DOI: 10.1097/INF.0000000000001302

08913668

15320987

http://hdl.handle.net/11268/5444

10.1097/INF.0000000000001302

Idioma(s)

eng

Direitos

openAccess

Palavras-Chave #Pediatría #Farmacología #Vacunación infantil #Salud #Pediatría #Farmacología #Vacunación
Tipo

article