Targeting microRNAs involved in the BDNF signaling impairment in neurodegenerative diseases
| Data(s) |
25/05/2016
25/05/2016
2016
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|---|---|
| Resumo |
Neurodegenerative diseases are becoming an ever-increasing problem in aging populations. Low levels of brain-derived neurotrophic factor (BDNF) have previously been associated with the pathogenesis of numerous neurodegenerative diseases. Recently, microRNAs (miRNAs) have been proposed as potential novel therapeutic targets for treating various diseases of the central nervous system (CNS), and interestingly, few studies have reported several miRNAs that downregulate the expression levels of BDNF. However, substantial challenges exist when attempting to translate these findings into practical anti-miRNA therapeutics, especially when the targets remain inside the CNS. Thus, in this review, we summarize the specific molecular mechanisms by which several miRNAs negatively modulate the expressions of BDNF, address the potential clinical difficulties that can be faced during the development of anti-miRNA-based therapeutics and propose strategies to overcome these challenges. SIN FINANCIACIÓN 3.692 JCR (2015) Q2, 75/256 Neurosciences UEM |
| Identificador |
You, H. J., Park, J. H., Pareja Galeano, H., Lucía Mulas, A., & Shin, J. (2016). Targeting microRNAs involved in the BDNF signaling impairment in neurodegenerative diseases. Neuromolecular Medicine, 18(4), 540-550. DOI: 10.1007/s12017-016-8407-9 15351084 15591174 http://hdl.handle.net/11268/5179 10.1007/s12017-016-8407-9 |
| Idioma(s) |
eng |
| Direitos |
openAccess |
| Palavras-Chave | #Enfermedades neurodegenerativas #Enfermedad del sistema nervioso |
| Tipo |
article |
