Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery


Autoria(s): Oliveira, Paula Alexandra; Costa, Rui Gil da; Nóbrega, Carmen; Rodrigues, Regina Arantes; Leite, Rosário Pinto
Data(s)

03/01/2017

03/01/2017

28/04/2016

Resumo

Urinary bladder cancer (UBC) is the second most frequent malignancy of the urinary system and the ninth most common cancer worldwide, affecting individuals over the age of 65. Several investigations have embarked on advancing knowledge of the mechanisms underlying urothelial carcinogenesis, understanding the mechanisms of antineoplastic drugs resistance and discovering new antineoplastic drugs. In vitro and in vivo models are crucial for providing additional insights into the mechanisms of urothelial carcinogenesis. With these models, various molecular pathways involved in urothelial carcinogenesis have been discovered, allowing therapeutic manipulation.

info:eu-repo/semantics/publishedVersion

Identificador

Oliveira, P.A., Costa, R. M.G., Nóbrega, C.V., Rodrigues, R.A. & Leite, R. P. (2016). Challenges with in vitro and in vivo experimental models of urinary bladder cancer for novel drug discovery. "Expert opinion on drug discovery", 11(6),599-607. Retrieved fromhttp://www.tandfonline.com/doi/abs/10.1080/17460441.2016.1174690?journalCode=iedc20.

http://hdl.handle.net/10400.19/3587

Idioma(s)

eng

Publicador

Taylor & Francis

Relação

6;

http://www.tandfonline.com/doi/abs/10.1080/17460441.2016.1174690?journalCode=iedc20

Direitos

openAccess

http://creativecommons.org/licenses/by/4.0/

Palavras-Chave #Animal models #antineoplastic drugs #cell culture #treatment #tumor #urothelial
Tipo

article