Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to β-lactams in Haemophilus influenzae


Autoria(s): Søndergaard, Annette; San Millan, Alvaro; Santos López, Alfonso; Nielsen, Signe M; González Zorn, Bruno; Nørskov-Lauritsen, Niels
Data(s)

01/09/2012

Resumo

TEM-1 is the dominant β-lactamase of Haemophilus influenzae and can be located on small plasmids. Three distinct plasmids with sizes from 4,304 to 5,646 nucleotides (nt) were characterized: pA1606, pA1209, and pPN223. In addition to TEM-1 and a replication enzyme of the Rep 3 superfamily, pA1606 carries a Tn3 resolvase gene and pA1606 and pA1209 carry an open reading frame (ORF) similar to a plasmid recombination enzyme gene described in Gram-positive bacteria. The plasmids transformed strain Rd to the ampicillin-resistant phenotype.

Formato

application/pdf

Identificador

http://eprints.ucm.es/39668/1/509.pdf

Idioma(s)

en

Publicador

American Society for Microbiology

Relação

http://eprints.ucm.es/39668/

http://aac.asm.org/content/56/9/4958.full

doi:10.1128/AAC.00408-12

Direitos

info:eu-repo/semantics/restrictedAccess

Palavras-Chave #Veterinaria
Tipo

info:eu-repo/semantics/article

PeerReviewed