Anti-inflammatory activity and mechanisms of a lipid extract from hard-shelled mussel (mytilus coruscus) in mice with dextran sulphate sodium-induced colitis


Autoria(s): Wang, Fenglei; Fu, Yuanqing; Cai, Wenwen; Sinclair, Andrew J; Li, Duo
Data(s)

01/05/2016

Resumo

The anti-inflammatory effect of a lipid extract from hard-shelled mussel (HMLE) on dextran sulphate sodium (DSS)-induced colitis in mice was investigated. Salicylazosulphapyridine (SASP) and different doses of HMLE were administered by gastric gavage. HMLE significantly attenuated DSS-induced colitis disease activity index scores, tissue damage, splenic enlargement and colon myeloperoxidase accumulation. In addition, HMLE improved colon oxidative stress and production and expression of anti-inflammatory cytokine, interleukin (IL)-10, while HMLE inhibited the abnormal productions and mRNA expressions of pro-inflammatory cytokines, namely tumour necrosis factor-α, IL-1β, and IL-6, as well as the expression of key molecules in the toll-like receptor (TLR)-4/nuclear factor (NF)-κB signalling pathway. These findings suggest that HMLE has an anti-inflammatory effect on DSS-induced colitis, equivalent to that of SASP, and this effect might be related to the regulation of inflammatory mediators and key molecules in the TLR-4/NF-κB pathway.

Identificador

http://hdl.handle.net/10536/DRO/DU:30085962

Idioma(s)

eng

Publicador

Elsevier

Relação

http://dro.deakin.edu.au/eserv/DU:30085962/sinclair-antiinflammatory-2016.pdf

http://www.dx.doi.org/10.1016/j.jff.2016.03.002

Direitos

2016, Elsevier

Palavras-Chave #Science & Technology #Life Sciences & Biomedicine #Food Science & Technology #Hard-shelled mussel #Lipid extract #Salicylazosulphapyridine #Colitis #Anti-inflammatory #TLR-4/NF-kappa B pathway #INFLAMMATORY-BOWEL-DISEASE #GREEN-LIPPED MUSSEL #ULCERATIVE-COLITIS #PERNA-CANALICULUS #FATTY-ACIDS #FISH-OIL #KAPPA-B #RATS #THERAPY #ARTHRITIS
Tipo

Journal Article