Epidemiological and evolutionary inference of the transmission network of the 2014 highly pathogenic Avian Influenza H5N2 outbreak in British Columbia, Canada


Autoria(s): Xu, Wanhong; Berhane, Yohannes; Dubé, Caroline; Liang, Binhua; Pasick, John; VanDomselaar, Gary; Alexandersen, Soren
Data(s)

01/01/2016

Resumo

The first North American outbreak of highly pathogenic avian influenza (HPAI) involving a virus of Eurasian A/goose/Guangdong/1/1996 (H5N1) lineage began in the Fraser Valley of British Columbia, Canada in late November 2014. A total of 11 commercial and 1 non-commercial (backyard) operations were infected before the outbreak was terminated. Control measures included movement restrictions that were placed on a total of 404 individual premises, 150 of which were located within a 3 km radius of an infected premise(s) (IP). A complete epidemiological investigation revealed that the source of this HPAI H5N2 virus for 4 of the commercial IPs and the single non-commercial IP likely involved indirect contact with wild birds. Three IPs were associated with the movement of birds or service providers and localized/environmental spread was suspected as the source of infection for the remaining 4 IPs. Viral phylogenies, as determined by Bayesian Inference and Maximum Likelihood methods, were used to validate the epidemiologically inferred transmission network. The phylogenetic clustering of concatenated viral genomes and the median-joining phylogenetic network of the viruses supported, for the most part, the transmission network that was inferred by the epidemiologic analysis.

Identificador

http://hdl.handle.net/10536/DRO/DU:30085565

Idioma(s)

eng

Publicador

Nature Publishing Group

Relação

http://dro.deakin.edu.au/eserv/DU:30085565/alexandersen-epidemiological-2016.pdf

http://www.dx.doi.org/10.1038/srep30858

Direitos

2016, The Authors

Palavras-Chave #influenza virus #phylogeny #Science & Technology #Multidisciplinary Sciences #Science & Technology - Other Topics
Tipo

Journal Article