Estimating the risk of type-2 diabetes using obese-years in a contemporary population of the Framingham Study
Data(s) |
01/01/2016
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Resumo |
BACKGROUND: We have recently demonstrated that an obese-years construct is a better predictor of the risk of diabetes than the severity of body weight alone. However, these risk estimates were derived from a population cohort study initiated in 1948 that might not apply to the current population. <br /><br />OBJECTIVE: To validate an obese-years construct in estimating the risk of type-2 diabetes in a more contemporary cohort study. <br /><br />DESIGN: A total of 5,132 participants of the Framingham Offspring Study, initiated in 1972, were followed up for 45 years. Body mass index (BMI) above 29 kg/m(2) was multiplied by the number of years lived with obesity at that BMI to define the number of obese-years. Time-dependent Cox regression was used to explore the association. <br /><br />RESULTS: The risk of type-2 diabetes increased significantly with increase in obese-years. Adjusted hazard ratios increased by 6% (95% CI: 5-7%) per additional 10 points of obese-years. This ratio was observed to be similar in both men and women, but was 4% higher in current smokers than in never/ex-smokers. The Akaike Information Criterion confirmed that the Cox regression model with the obese-years construct was a stronger predictor of the risk of diabetes than a model including either BMI or the duration of obesity alone. <br /><br />CONCLUSIONS: In a contemporary cohort population, it was confirmed that the obese-years construct is strongly associated with an increased risk of type-2 diabetes. This suggests that both severity and the duration of obesity should be considered in future estimations of the burden of disease associated with obesity. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Co-Action Publishing |
Relação |
http://dro.deakin.edu.au/eserv/DU:30085198/wong-estimatingriskoftype2-2016.pdf http://www.globalhealthaction.net/index.php/gha/article/view/30421 |
Direitos |
2016, The Authors |
Palavras-Chave | #BMI #obese-years #obesity #offspring Framingham #type-2 diabetes |
Tipo |
Journal Article |