Cord blood monocyte-derived inflammatory cytokines suppress IL-2 and induce nonclassic "T(H)2-type" immunity associated with development of food allergy
Data(s) |
13/01/2016
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Resumo |
Food allergy is a major health burden in early childhood. Infants who develop food allergy display a proinflammatory immune profile in cord blood, but how this is related to interleukin-4 (IL-4)/T helper 2 (T(H)2)-type immunity characteristic of allergy is unknown. In a general population-derived birth cohort, we found that in infants who developed food allergy, cord blood displayed a higher monocyte to CD4(+) T cell ratio and a lower proportion of natural regulatory T cell (nT(reg)) in relation to duration of labor. CD14(+) monocytes of food-allergic infants secreted higher amounts of inflammatory cytokines (IL-1β, IL-6, and tumor necrosis factor-α) in response to lipopolysaccharide. In the presence of the mucosal cytokine transforming growth factor-β, these inflammatory cytokines suppressed IL-2 expression by CD4(+) T cells. In the absence of IL-2, inflammatory cytokines decreased the number of activated nT(reg) and diverted the differentiation of both nT(reg) and naïve CD4(+) T cells toward an IL-4-expressing nonclassical TH2 phenotype. These findings provide a mechanistic explanation for susceptibility to food allergy in infants and suggest anti-inflammatory approaches to its prevention. |
Identificador | |
Idioma(s) |
eng |
Publicador |
American Association for the Advancement of Science |
Relação |
http://dro.deakin.edu.au/eserv/DU:30085114/collier-cordbloodmonocyte-2016.pdf http://www.dx.doi.org/10.1126/scitranslmed.aad4322 |
Direitos |
2016, American Association for the Advancement of Science |
Palavras-Chave | #BIS Investigator Group #Science & Technology #Life Sciences & Biomedicine #Cell Biology #Medicine, Research & Experimental #Research & Experimental Medicine |
Tipo |
Journal Article |