Challenges and opportunities for siRNA-based cancer treatment
Data(s) |
28/02/2017
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Resumo |
As one of the life-threatening diseases involving multi-step genetic and epigenetic disorders, cancer has long been a dynamic research area for siRNA-based therapy as half of the current siRNA-based clinical trials are involved in oncology. However, despite consistent enthusiasm in the academic world, siRNA-based cancer treatment still faces obstacles and difficulties in clinical development. In this article, we discuss key challenges facing siRNA-based cancer treatment revealed from recent clinical and preclinical studies, including chemical modification, tumour penetration, endosomal escape, target selection and off-target effects. In addition, opportunities and avenues for translating siRNA technology from bench to oncologic clinics are explored. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Elsevier |
Relação |
http://dro.deakin.edu.au/eserv/DU:30084779/wang-challengesandopp-inpress-2016.pdf http://dro.deakin.edu.au/eserv/DU:30084779/wang-challengesandopportunities-2017.pdf http://www.dx.doi.org/10.1016/j.canlet.2016.03.045 |
Direitos |
2016, Elsevier Ireland |
Palavras-Chave | #RNA interference #tumour #nanoparticle #EPR effect #endosome escape #off-target |
Tipo |
Journal Article |