Cancer stem cell targeted therapy: progress amid controversies


Autoria(s): Wang, Tao; Shigdar, Sarah; Gantier, Michael P.; Hou, Yingchun; Wang, Li; Li, Yong; Al Shamaileh, Hadi; Yin, Wang; Zhou, Shu Feng; Zhao, Xinhan; Duan, Wei
Data(s)

19/10/2015

Resumo

Although cancer stem cells have been well characterized in numerous malignancies, the fundamental characteristics of this group of cells, however, have been challenged by some recent observations: cancer stem cells may not necessary to be rare within tumors; cancer stem cells and non-cancer stem cells may undergo reversible phenotypic changes; and the cancer stem cells phenotype can vary substantially between patients. Here the current status and progresses of cancer stem cells theory is illustrated and via providing a panoramic view of cancer therapy, we addressed the recent controversies regarding the feasibility of cancer stem cells targeted anti-cancer therapy.

Identificador

http://hdl.handle.net/10536/DRO/DU:30080436

Idioma(s)

eng

Publicador

Impact Journals

Relação

http://dro.deakin.edu.au/eserv/DU:30080436/wang-cancerstem-2015.pdf

http://www.dx.doi.org/10.18632/oncotarget.6176

Direitos

2015, The Authors

Palavras-Chave #anti-cancer treatment #cancer #cancer stem cell #cancer stem cell marker #cancer stem cell model
Tipo

Journal Article