Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors
| Data(s) |
12/10/2016
01/07/2016
01/08/2017
|
|---|---|
| Resumo |
This is a non-final version of an article published in final form in AIDS. 2016 Jul 17;30(11):1691-701. "Objective: To develop a novel and potent fusion inhibitor of HIV infection based on a rational strategy for synthetic antibody library construction. Design: The reduced molecular weight of single-domain antibodies (sdAbs) allows targeting of cryptic epitopes, the most conserved and critical ones in the context of HIV entry. Heavy-chain sdAbs from camelids are particularly suited for this type of epitope recognition because of the presence of long and flexible antigen-binding regions [complementary-determining regions (CDRs)]." |
| Identificador |
AIDS. 2016 Jul 17;30(11):1691-701. doi: 10.1097/QAD.0000000000001108. 1691-1701 http://hdl.handle.net/10400.26/15096 0.1097/QAD.0000000000001108 |
| Idioma(s) |
eng |
| Publicador |
Wolters Kluwer |
| Relação |
info:eu-repo/grantAgreement/FCT/3599-PPCDT/135844/PT info:eu-repo/grantAgreement/FCT/3599-PPCDT/122400/PT info:eu-repo/grantAgreement/FCT/3599-PPCDT/123654/PT info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F73838%2F2010/PT http://journals.lww.com/aidsonline/pages/articleviewer.aspx?year=2016&issue=07170&article=00004&type=abstract |
| Direitos |
embargoedAccess |
| Palavras-Chave | #HIV fusion inhibitor #HR1 #Single-domain antibody #Synthetic library #Variable light-chain |
| Tipo |
article |
