Antiophidic Solanidane Steroidal Alkaloids from Solanum campaniforme

Autoria(s): Torres, Maria Conceicao M.; Pinto, Francisco das Chagas L.; Braz-Filho, Raimundo; Silveira, Edilberto R.; Pessoa, Otilia Deusdenia L.; Jorge, Roberta Jeane Bezerra; Ximenes, Rafael Matos; Azul Monteiro, Helena Serra; Azul Monteiro Evangelista, Janaina Serra; Diz-Filho, Eduardo B. S.; Toyama, Marcos Hikari
Contribuinte(s)

Universidade Estadual Paulista (UNESP)
Data(s)

20/05/2014

25/10/2016

20/05/2014

25/10/2016

01/10/2011
Resumo

Three new solanidane alkaloids bearing a 22,23-epoxy ring (1-3) and four known compounds were isolated from leaves of Solanum campaniforme. The structures were determined using spectroscopic techniques, including ID and 2D NMR, and HRESIMS experiments. The antiophidic activity of the alkaloids was tested against Bothrops pauloensis venom. Compounds 1-3 completely inhibited myotoxicity without inhibiting phospholipase A(2) activity of the venom, while hemorrhage and skin necrosis were significantly reduced in the presence of alkaloids 1 and 2.

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Identificador

Journal of Natural Products. Washington: Amer Chemical Soc, v. 74, n. 10, p. 2168-2173, 2011.

0163-3864

http://hdl.handle.net/11449/327

http://acervodigital.unesp.br/handle/11449/327

10.1021/np200479a

WOS:000296206500019

http://dx.doi.org/10.1021/np200479a
Idioma(s)

eng
Publicador

Amer Chemical Soc
Relação

Journal of Natural Products
Direitos

info:eu-repo/semantics/closedAccess
Tipo

outro
Acesso ao item digital