Anti-inflammatory potential of mushroom extracts and isolated metabolites


Autoria(s): Taofiq, Oludemi; Martins, Anabela; Barreiro, M.F.; Ferreira, Isabel C.F.R.
Data(s)

03/10/2016

03/10/2016

2016

Resumo

Background: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach: The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action. Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions: The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites. Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators.

Identificador

Taofiq, Oludemi; Martins, Anabela; Barreiro, M.F.; Ferreira, Isabel C.F.R. (2016) - Anti-inflammatory potential of mushroom extracts and isolated metabolites. Trends in Food Science & Technology. ISSN 0924-2244. 50, p. 193-210

0924-2244

http://hdl.handle.net/10198/13350

10.1016/j.tifs.2016.02.005

Idioma(s)

eng

Direitos

openAccess

http://creativecommons.org/licenses/by/4.0/

Palavras-Chave #Inflammation #NSAIDs #Mushrooms #Bioactive compounds
Tipo

article