Physicochemical Stability of Poly(lactide-co-glycolide) Nanocapsules Containing the Local Anesthetic Bupivacaine


Autoria(s): Moraes, Carolina M.; De Paula, Eneida; Rosa, Andre H.; Fraceto, Leonardo F.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

25/10/2016

20/05/2014

25/10/2016

01/01/2010

Resumo

This paper describes the preparation of poly(DL-lactide-co-glicolide) (PLGA) nanocapsules as a drug carrier system for the local anesthetic bupivacaine. The system was characterized and its stability investigated. The results showed a size distribution with a polydispersity index of 0.12, an average diameter of 148 nm, a zeta potential of -43.5 mV and an entrapment efficiency of 75.8%. The physicochemical properties of polymeric nanocapsule suspensions (average diameter, polydispersity, zeta potential and drug association efficiency) were evaluated as a function of time to determine the formulation stability. The formulation did not display major changes in these properties over the time, and it was considered stable up to 120 days of storage at room temperature. The results reported here which refer to the initial characterization of these new formulations for the local anesthetic bupivacaine show a promising potential for future in vivo studies.

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Identificador

Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 21, n. 6, p. 995-1000, 2010.

0103-5053

http://hdl.handle.net/11449/186

http://acervodigital.unesp.br/handle/11449/186

10.1590/S0103-50532010000600008

S0103-50532010000600008

WOS:000278745400008

0000-0002-2042-018X

http://dx.doi.org/10.1590/S0103-50532010000600008

Idioma(s)

eng

Publicador

Soc Brasileira Quimica

Relação

Journal of the Brazilian Chemical Society

Direitos

info:eu-repo/semantics/openAccess

Palavras-Chave #bupivacaine #local anesthetic #polymeric nanocapsules #PLGA #physical-chemical stability
Tipo

outro