16α-[18F]-fluoro-17ß-oestradiol ([18F]FES): A biomarker for imaging oestrogen receptor expression with positron emission tomography (PET)
| Contribuinte(s) |
Micro et nanomédecines biomimétiques (MINT) ; Université d'Angers (UA) - Institut National de la Santé et de la Recherche Médicale (INSERM) Centre Hospitalier Universitaire d'Angers (CHU Angers) ; PRES Université Nantes Angers Le Mans [UNAM] |
|---|---|
| Data(s) |
2015
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| Resumo |
International audience <p>Oestrogens play a major role in the development of gynaecological oestrogen-dependent diseases that overexpress oestrogen receptors (ER+). The ER status is assessed using immunohistochemistry analysis of tissues samples. It is believed that a non-invasive method such as positron emission tomography (PET) that would accurately evaluate and quantify in vivo the presence of ER could play an important role in managing such diseases. PET using fluorinated oestrogen analogues may be helpful in selecting patients who will benefit from endocrine therapy or could be used to identify high-grade cancer with poorer prognosis. Among more than 20 fluorinated oestrogens analogues that have been proposed as PET tracer candidates, 16a-[18F]fluoro-17b-oestradiol ([18F]FES) has been the most actively investigated in preclinical and clinical studies.</p> |
| Identificador |
hal-01392432 https://hal.archives-ouvertes.fr/hal-01392432 DOI : 10.1016/j.mednuc.2015.02.005 OKINA : ua9083 |
| Idioma(s) |
en |
| Publicador |
HAL CCSD |
| Relação |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mednuc.2015.02.005 |
| Fonte |
ISSN: 09281258 Médecine Nucléaire https://hal.archives-ouvertes.fr/hal-01392432 Médecine Nucléaire, 2015, 39 (1), pp.64-70. <10.1016/j.mednuc.2015.02.005> |
| Palavras-Chave | #[SDV] Life Sciences [q-bio] |
| Tipo |
info:eu-repo/semantics/article Journal articles |
