Low- vs. high-glycemic load diets: effects on postprandial plasma free fatty acids

Thesis (Master's)--University of Washington, 2016-06

ABSTRACT Introduction: Low-glycemic load diets are commonly prescribed for blood glucose management. Currently, however, it is not clear as to whether the diet has any implications, positive or negative, on cardiovascular health in healthy individuals. Methods: Using data collected from the Carbohydrates and Related Biomarkers (CARB) Study, conducted at the Fred Hutchinson Cancer Research Center, we analyzed the effects of a high- vs. low-glycemic load diet on fasting lipids and postprandial plasma free fatty acid levels in healthy, non-insulin resistant, adults. Participants were randomized to complete either a high- or low-glycemic load diet for 28 days, followed by a washout period of 28 days, and then complete the opposite diet for 28 days. Results: We found that a high- vs. low-glycemic load diet did not have any significant effect on plasma free fatty acid levels in the eight hour time period following a test breakfast. Conclusions: Glycemic load does not appear to affect cardiovascular health in the short-term, however, further research is needed to determine any long-term implications. Based on our findings, we cannot support a recommendation that a low-GL diet is protective against cardiovascular disease in healthy individuals.