Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low
| Data(s) |
22/07/2016
22/07/2016
2012
|
|---|---|
| Resumo |
<p>[EN]Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial. In some recent meta-analyses in which significant results have been reported, the associations disappeared after adjustment for body mass index (BMI). However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet).</p> <p>[EN]Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial. In some recent meta-analyses in which significant results have been reported, the associations disappeared after adjustment for body mass index (BMI). However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet).</p> |
| Identificador |
http://hdl.handle.net/10553/17988 <p>10.1186/1475-2840-11-137</p> |
| Idioma(s) |
eng |
| Direitos |
Acceso libre by-nc-nd |
| Fonte |
<p>Cardiovascular Diabetology 2012, 11:137</p> |
| Palavras-Chave | #3206 Ciencias de la nutrición |
| Tipo |
info:eu-repo/semantics/article |
