Low frequency of the TEL/AML1 fusion gene in acute lymphoblastic leukaemia in Spain.
| Data(s) |
01/12/1999
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| Resumo |
We report on a series of Spanish patients with acute lymphoblastic leukaemia in whom the t(12;21) [TEL/AML1] translocation could not be identified with two sensitive techniques: reverse transcript-polymerase chain reaction (RT-PCR) and fluorescence in-situ hybridization (FISH). 101 cases were analysed: 38 children (29 B-cell precursor; nine T-cell precursor) and 63 adults (48 B-cell precursor; 15 T-cell precursor). Specific RT-PCR to amplify the TEL/AML1 fusion transcript was negative in all 101 cases. Moreover, all 38 paediatric samples were also negative by interphase FISH analysis for the presence of the TEL/AML1 fusion. These results suggest the existence of geographic/race variations in the genotype of acute lymphoblastic leukaemia (ALL). |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
García-Sanz , R , Alaejos , I , Orfão , A , Rasillo , A , Chillón , M C , Tabernero , M D , Mateos , M V , López-Pérez , R , González , D , Balanzategui , A , González , M , San Miguel , J F & Bortolucci , A 1999 , ' Low frequency of the TEL/AML1 fusion gene in acute lymphoblastic leukaemia in Spain. ' British Journal of Haematology , vol 107 , no. 3 , pp. 667-669 . |
| Palavras-Chave | #Adolescent #Adult #Child #Chromosomes, Human, Pair 12 #Chromosomes, Human, Pair 21 #Core Binding Factor Alpha 2 Subunit #Female #Gene Frequency #Humans #In Situ Hybridization, Fluorescence #Male #Neoplasm Proteins #Oncogene Proteins, Fusion #Precursor Cell Lymphoblastic Leukemia-Lymphoma #Reverse Transcriptase Polymerase Chain Reaction #Spain #Translocation, Genetic |
| Tipo |
article |
