Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica


Autoria(s): Chuah, Candy; Jones, Malcolm K; McManus, Donald P; Nawaratna, Sujeevi K; Burke, Melissa L; Owen, Helen C; Ramm, Grant A; Gobert, Geoffrey N
Data(s)

01/04/2016

Resumo

<p>For hepatic schistosomiasis the egg-induced granulomatous response and the development of extensive fibrosis are the main pathologies. We used a Schistosoma japonicum-infected mouse model to characterise the multi-cellular pathways associated with the recovery from hepatic fibrosis following clearance of the infection with the anti-schistosomal drug, praziquantel. In the recovering liver splenomegaly, granuloma density and liver fibrosis were all reduced. Inflammatory cell infiltration into the liver was evident, and the numbers of neutrophils, eosinophils and macrophages were significantly decreased. Transcriptomic analysis revealed the up-regulation of fatty acid metabolism genes and the identification of Peroxisome proliferator activated receptor alpha as the upstream regulator of liver recovery. The aryl hydrocarbon receptor signalling pathway which regulates xenobiotic metabolism was also differentially up-regulated. These findings provide a better understanding of the mechanisms associated with the regression of hepatic schistosomiasis.</p>

Identificador

http://pure.qub.ac.uk/portal/en/publications/characterising-granuloma-regression-and-liver-recovery-in-a-murine-model-of-schistosomiasis-japonica(56e04b8d-c389-4cca-bbc1-0f0c06dcbd18).html

http://dx.doi.org/10.1016/j.ijpara.2015.12.004

Idioma(s)

eng

Direitos

info:eu-repo/semantics/closedAccess

Fonte

Chuah , C , Jones , M K , McManus , D P , Nawaratna , S K , Burke , M L , Owen , H C , Ramm , G A & Gobert , G N 2016 , ' Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica ' International Journal for Parasitology , vol 46 , no. 4 , pp. 239-52 . DOI: 10.1016/j.ijpara.2015.12.004

Tipo

article