Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate
| Data(s) |
17/08/2016
17/08/2016
30/05/2013
16/08/2016
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|---|---|
| Resumo |
An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup. |
| Formato |
application/pdf |
| Identificador |
Slattery, C. N., Deasy, R. E., Maguire, A. R., Kopach, M. E., Singh, U. K., Argentine, M. D., Trankle, W. G., Scherer, R. B. and Moynihan, H. A. (2013) 'Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate', Journal of Organic Chemistry, 78(12), pp. 5955-5963. http://dx.doi.org/10.1021/jo400647t 78 12 5955 5963 0022-3263 http://hdl.handle.net/10468/2998 10.1021/jo400647t Journal of Organic Chemistry |
| Idioma(s) |
en |
| Publicador |
American Chemical Society |
| Direitos |
© 2013 American Chemical Society. This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in The Journal of Organic Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/jo400647t |
| Palavras-Chave | #Efficient process #Formylation #Hydride reduction #Hydroxymethylation #Pharmaceutical intermediates #Scale-up #Synthetic approach #Hydroxymethyl groups |
| Tipo |
Article (peer-reviewed) |
