The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development.


Autoria(s): Belsky, DW; Moffitt, TE; Corcoran, DL; Domingue, B; Harrington, H; Hogan, S; Houts, R; Ramrakha, S; Sugden, K; Williams, BS; Poulton, R; Caspi, A
Cobertura

United States

Data(s)

01/07/2016

Resumo

A previous genome-wide association study (GWAS) of more than 100,000 individuals identified molecular-genetic predictors of educational attainment. We undertook in-depth life-course investigation of the polygenic score derived from this GWAS using the four-decade Dunedin Study (N = 918). There were five main findings. First, polygenic scores predicted adult economic outcomes even after accounting for educational attainments. Second, genes and environments were correlated: Children with higher polygenic scores were born into better-off homes. Third, children's polygenic scores predicted their adult outcomes even when analyses accounted for their social-class origins; social-mobility analysis showed that children with higher polygenic scores were more upwardly mobile than children with lower scores. Fourth, polygenic scores predicted behavior across the life course, from early acquisition of speech and reading skills through geographic mobility and mate choice and on to financial planning for retirement. Fifth, polygenic-score associations were mediated by psychological characteristics, including intelligence, self-control, and interpersonal skill. Effect sizes were small. Factors connecting DNA sequence with life outcomes may provide targets for interventions to promote population-wide positive development.

Formato

957 - 972

Identificador

http://www.ncbi.nlm.nih.gov/pubmed/27251486

0956797616643070

Psychol Sci, 2016, 27 (7), pp. 957 - 972

http://hdl.handle.net/10161/12447

1467-9280

Idioma(s)

eng

Relação

Psychol Sci

10.1177/0956797616643070

Palavras-Chave #adult development #behavior genetics #genetics #intelligence #personality
Tipo

Journal Article