Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal D1 neurons


Autoria(s): Zhang, Zhe; Hao, Chan-Juan; Li, Chang-Gui; Zang, Dong-Jie; Zhao, Jing; Li, Xiao-Nan; Wei, Ai-Hua; Wei, Zong-Bo; Yang, Lin; He, Xin; Zhen, Xue-Chu; Gao, Xiang; Speakman, John R; Li, Wei
Contribuinte(s)

University of Aberdeen, Natural & Computing Sciences

University of Aberdeen, School of Biological Sciences, Biological Sciences

University of Aberdeen, Environment and Food Security

University of Aberdeen, School of Biological Sciences

Data(s)

25/08/2016

25/08/2016

13/02/2014

Resumo

Funding: This work was partially supported by grants from National Basic Research Program of China (2013CB530605; 2014CB942803), from National Natural Science Foundation of China 1230046; 31071252; 81101182) and from Chinese Academy of Sciences (KSCX2-EW-R-05, KJZD-EW-L08). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Peer reviewed

Publisher PDF

Identificador

Zhang , Z , Hao , C-J , Li , C-G , Zang , D-J , Zhao , J , Li , X-N , Wei , A-H , Wei , Z-B , Yang , L , He , X , Zhen , X-C , Gao , X , Speakman , J R & Li , W 2014 , ' Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal D1 neurons ' PLoS Genetics , vol 10 , no. 2 , e1004124 . , 10.1371/journal.pgen.1004124

1553-7390

PURE: 70070438

PURE UUID: eba7ec42-70a8-4463-936e-d70c882a2698

PubMed: 24550737

http://hdl.handle.net/2164/7383

http://dx.doi.org/10.1371/journal.pgen.1004124

Idioma(s)

eng

Relação

PLoS Genetics

Direitos

Copyright: © 2014 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Palavras-Chave #Animals #Central Nervous System #Dopamine #Female #Humans #Male #Metabolic Syndrome X #Mice #Monosaccharide Transport Proteins #Mutation #Neurons #Obesity #Receptors, Dopamine D1 #Signal Transduction #Visual Cortex #QH301 Biology #QH301
Tipo

Journal article