EPI-001, a compound active against castration-resistant prostate cancer, targets transactivation unit 5 of the androgen receptor


Autoria(s): Moll, Eva De; Fenwick, R. Bryn; Phang, Christopher T.W.; Buzon, Victor; Szulc, Elzbieta; De La Fuente, Alex; Escobedo, Albert; Garcia, Jesus; Bertoncini, Carlos W.; Estebanez-Perpina, Eva; McEwan, Iain J.; Riera, Antoni; Salvatella, Xavier
Contribuinte(s)

University of Aberdeen, Medicine, Medical Sciences & Nutrition, Medical Sciences

Data(s)

05/08/2016

05/08/2016

29/06/2016

Resumo

ACKNOWLEDGEMENTS We thank J. M. Valverde (IRB) as well as the NMR facilities of the University of Barcelona (CCiT UB) and the Instituto de Química Física Rocasolano (IQFR, CSIC) for their assistance in, respectively, protein production and NMR. This work was supported by IRB, ICREA (X.S.), Obra Social “la Caixa” (Fellowship to E.D.M. and CancerTec grants to X.S.) MICINN (CTQ2009-08850 to X.S.), MINECO (BIO2012-31043 to X.S.; CTQ2014-56361-P to A.R), Marató de TV3 (102030 to X.S. and 102031 to E.E.P) the COFUND programme of the European Commission (C.T.W.P., A. R. and X.S.), the European Research Council (CONCERT, contract number 648201, to X.S.), the Ramón y Cajal program of MICINN (RYC-2011-07873 to C.W.B.) the Serra Hunter Programme (E.E.P.) and AGAUR (SGR-2014-56RR14 to E.E.P). IRB Barcelona is the recipient of a Severo Ochoa Award of Excellence from MINECO (Government of Spain)

Peer reviewed

Postprint

Identificador

Moll , E D , Fenwick , R B , Phang , C T W , Buzon , V , Szulc , E , De La Fuente , A , Escobedo , A , Garcia , J , Bertoncini , C W , Estebanez-Perpina , E , McEwan , I J , Riera , A & Salvatella , X 2016 , ' EPI-001, a compound active against castration-resistant prostate cancer, targets transactivation unit 5 of the androgen receptor ' ACS Chemical Biology . , 10.1021/acschembio.6b00182

1554-8929

PURE: 68826843

PURE UUID: 186e64e2-2f32-4949-9680-b3349615a24b

http://hdl.handle.net/2164/7155

http://dx.doi.org/10.1021/acschembio.6b00182

Idioma(s)

eng

Relação

ACS Chemical Biology

Direitos

“This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Chemical Biology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].”

Palavras-Chave #R Medicine #R
Tipo

Journal article