A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2′,4′-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives


Autoria(s): Lazzari, Paolo; Distinto, Rita; Manca, Ilaria; Baillie, Gemma; Murineddu, Gabriele; Pira, Marilena; Falzoi, Matteo; Sani, Monica; Morales, Paula; Ross, Ruth; Zanda, Matteo; Jagerovic, Nadine; Pinna, Gerard Aime
Contribuinte(s)

University of Aberdeen, School of Biological Sciences, Biological Sciences

University of Aberdeen, Medicine, Medical Sciences & Nutrition, Medical Sciences

University of Aberdeen, Medical Sciences - Cardiovascular Group

Data(s)

05/08/2016

05/08/2016

04/10/2016

Resumo

We thank European Commission (project “PET BRAIN: Mapping the brain with PET radiolabeled cannabinoid CB1 ligands”; FP7-People-2009-IAPP; Grant Agreement N.25142).

Peer reviewed

Postprint

Formato

15

Identificador

Lazzari , P , Distinto , R , Manca , I , Baillie , G , Murineddu , G , Pira , M , Falzoi , M , Sani , M , Morales , P , Ross , R , Zanda , M , Jagerovic , N & Pinna , G A 2016 , ' A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2′,4′-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives ' European Journal of Medicinal Chemistry , vol 121 , pp. 194-208 . , 10.1016/j.ejmech.2016.05.011

0223-5234

PURE: 66637117

PURE UUID: c627ba0b-7b90-4a66-bd46-37e8827264ae

http://hdl.handle.net/2164/7057

http://dx.doi.org/10.1016/j.ejmech.2016.05.011

Idioma(s)

eng

Relação

European Journal of Medicinal Chemistry

Direitos

© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

Palavras-Chave #cannabinoids #endocannabinoid system (ECS) #8-chloro-1-(2’,4’-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide #cannabinoid receptor binding assays #CB1 receptor ligands #QH301 Biology #QH301
Tipo

Journal article