Circadian gene variants and susceptibility to type 2 diabetes:a pilot study
| Data(s) |
02/04/2012
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| Resumo |
Disruption of endogenous circadian rhythms has been shown to increase the risk of developing type 2 diabetes, suggesting that circadian genes might play a role in determining disease susceptibility. We present the results of a pilot study investigating the association between type 2 diabetes and selected single nucleotide polymorphisms (SNPs) in/near nine circadian genes. The variants were chosen based on their previously reported association with prostate cancer, a disease that has been suggested to have a genetic link with type 2 diabetes through a number of shared inherited risk determinants. |
| Formato |
application/pdf |
| Identificador |
http://eprints.aston.ac.uk/16948/1/Circadian_Gene_Variants_and_Susceptibility_to_Type_2_Diabetes.pdf Kelly, M. Ann; Rees, Simon D.; Hydrie, M. Zafar I.; Shera, A. Samad; Bellary, Srikanth; O'Hare, J. Paul; Kumar, Sudhesh; Taheri, Shahrad; Basit, Abdul; Barnett, Anthony H.; , DIAGRAM Consortium and , SAT2D consortium (2012). Circadian gene variants and susceptibility to type 2 diabetes:a pilot study. PLoS ONE, 7 (4), |
| Relação |
http://eprints.aston.ac.uk/16948/ |
| Tipo |
Article PeerReviewed |
