Integrating in silico and in vitro analysis of peptide binding affinity to HLA-Cw*0102:a bioinformatic approach to the prediction of new epitopes


Autoria(s): Walshe, Valerie A.; Hattotuwagama, Channa K.; Doytchinova, Irini A.; Wong, MaiLee; Macdonald, Isabel K.; Mulder, Arend; Claas, Frans H.J.; Pellegrino, Pierre; Turner, Jo; Williams, Ian; Turnbull, Emma L.; Borrow, Persephone; Flower, Darren R
Data(s)

2009

Resumo

Predictive models of peptide-Major Histocompatibility Complex (MHC) binding affinity are important components of modern computational immunovaccinology. Here, we describe the development and deployment of a reliable peptide-binding prediction method for a previously poorly-characterized human MHC class I allele, HLA-Cw*0102.

Formato

application/pdf

Identificador

http://eprints.aston.ac.uk/16072/1/journal.pone.0008095.pdf

Walshe, Valerie A.; Hattotuwagama, Channa K.; Doytchinova, Irini A.; Wong, MaiLee; Macdonald, Isabel K.; Mulder, Arend; Claas, Frans H.J.; Pellegrino, Pierre; Turner, Jo; Williams, Ian; Turnbull, Emma L.; Borrow, Persephone and Flower, Darren R (2009). Integrating in silico and in vitro analysis of peptide binding affinity to HLA-Cw*0102:a bioinformatic approach to the prediction of new epitopes. PLoS ONE, 4 (11),

Relação

http://eprints.aston.ac.uk/16072/

Tipo

Article

PeerReviewed