The effect of genotype on receptor expression in human alcoholic brain


Autoria(s): Dodd, P. R.; Foley, P. F.; Buckley, S. T.; Eckert, A. L.; Innes, D. J.
Data(s)

01/01/2005

Resumo

Severe long-term alcohol misuse leads to localized brain damage that is prominent in superior frontal cortex but less so in other cortical areas e.g. primary motor. Alcohol dependence is also associated with several genetic markers. GABAA receptor expression differs selectively between alcoholics and controls in a manner that conforms to the pathology, whereas glutamate receptors are much less regionally variable in these subjects. We determined whether genotype differentiated the pharmacology of glutamate-NMDA receptors and the expression GABAA receptor subunits transcripts in a locally appropriate way so as to influence the severity of alcohol-induced brain damage.

Identificador

http://espace.library.uq.edu.au/view/UQ:102374

Idioma(s)

eng

Publicador

Blackwell

Palavras-Chave #Alcohol abuse #Brain #GABAA #Glutamate #EX #270201 Gene Expression #730205 Substance abuse #1109 Neurosciences
Tipo

Conference Paper