Sequence variation in the Newcastle disease virus genome
Contribuinte(s) |
Dr BWJ Mahy Editor in cief |
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Data(s) |
01/01/2006
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Resumo |
Full-length genome sequences of five virulent and five avirulent strains of Newcastle disease virus isolated between 1998 and 2002 in Victoria and New South Wales, Australia were determined. Comparisons between these strains revealed that coding sequence variability in the haemagglutinin-neuraminidase (HN), matrix (M) and phosphoprotein (P) gene sequences appeared to be more variable than in the fusion (F), nucleocapsid (N) and RNA dependent-RNA replicase (L) genes. Sequence analysis of a number of other isolates made during the recent virulent NDV outbreaks, also identified the presence of a number of variants with altered F gene cleavage sites, which resulted in altered biological properties of those viruses. Quasispecies analysis of a number of field isolates indicated the presence of virulent virus in one particular isolate. Gene sequence analysis of the progenitor virus isolated in 1998 showed very little sequence variation when compared to that of a progenitor-like virus isolated in 2001 demonstrating that in the field. viral genome sequence variation appears to be biologically restricted to that of a consensus sequence. (c) 2005 Elsevier B.V. All rights reserved. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Elsevier Science Bv |
Palavras-Chave | #Sequence Variability #Newcastle Disease Virus #Quasi Species #Virology #Hemagglutinin-neuraminidase Gene #Protein Cleavage Site #Nucleotide-sequence #F-protein #Virulent #Fusion #Glycosylation #Pathogenicity #Glycoproteins #Australia #C1 #270303 Virology #730101 Infectious diseases |
Tipo |
Journal Article |