Overcoming original antigenic sin to generate new CD8 T cell IFN-gamma responses in an antigen-experienced host
Contribuinte(s) |
R. Rich M. M. Hogan |
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Data(s) |
01/09/2006
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Resumo |
The failure to mount effective immunity to virus variants in a previously virus-infected host is known as original antigenic sin. We have previously shown that prior immunity to a virus capsid protein inhibits induction by immunization of an IFN-gamma CD8(+) T cell response to an epitope linked to the capsid protein. We now demonstrate that capsid protein-primed CD4(+) T cells secrete IL-10 in response to capsid protein presented by dendritic cells, and deviate CD8+ T cells responding to a linked MHC class I-restricted epitope to reduce IFN-gamma production. Neutralizing IL-10 while delivering further linked epitope, either in vitro or in vivo, restores induction by immunization of an Ag-specific IFN-gamma response to the epitope. This finding demonstrates a strategy for overcoming inhibition of MHC class I epitopes upon immunization of a host already primed to Ag, which may facilitate immunotherapy for chronic viral infection or cancer. |
Identificador | |
Idioma(s) |
eng |
Publicador |
American Association of Immunologists |
Palavras-Chave | #Immunology #Virus-like Particles #Papillomavirus-like Particles #Dendritic Cells #Presenting Cells #Ctl Epitopes #Immunity #Activation #Memory #Tc2 #Immunotherapy #C1 #320202 Cellular Immunology #730102 Immune system and allergy |
Tipo |
Journal Article |