Chronic smoking and alcoholism change expression of selective genes in the human prefrontal cortex


Autoria(s): Flatscher-Bader, T.; Wilce, P. A.
Data(s)

01/01/2006

Resumo

Background: Alcoholism is commonly associated with chronic smoking. A number of gene expression profiles of regions within the human mesocorticolimbic system have identified potential alcohol-sensitive genes; however, the influence of smoking on these changes was not taken into account. This study addressed the impact of alcohol and smoking on the expression of 4 genes, previously identified as alcoholism-sensitive. in the human prefrontal cortex (PFC). Methods: mRNA expression of apolipoprotein D, tissue inhibitor of the metalloproteinase 3, high-affinity glial glutamate transporter and midkine, was measured in the PFC of alcoholic Subjects and controls with and without smoking comorbidity using real-time polymerase chain reaction. Results: The results show that alcohol affects transcription of some of these genes. Additionally, smoking has a marked influence on gene expression. Conclusion: This study emphasizes the need for careful case selection in future gene expression studies to delineate the adaptive molecular process associated with smoking and alcohol.

Identificador

http://espace.library.uq.edu.au/view/UQ:79699

Idioma(s)

eng

Publicador

Blackwell Publishing

Palavras-Chave #Alcohol Dependence #Nicotine Dependence #Mesocorticolimbic System #Prefrontal Cortex #Substance Abuse #Ventral Tegmental Area #Apolipoprotein-d #Tissue Inhibitor #Chronic Nicotine #Frontal-cortex #Glutamate Receptors #Nucleus-accumbens #Cortical-neurons #Tobacco Smoking #Nmda Receptor #C1 #270107 Cell Neurochemistry #730104 Nervous system and disorders
Tipo

Journal Article