Calcium transport and signaling in the mammary gland: Targets for breast cancer


Autoria(s): Lee, W. J.; Monteith, G. R.; Roberts-Thomson, S. J.
Data(s)

01/01/2006

Resumo

The mammary gland is subjected to extensive calcium loads during lactation to support the requirements of milk calcium enrichment. Despite the indispensable nature of calcium homeostasis and signaling in regulating numerous biological functions, the mechanisms by which systemic calcium is transported into milk by the mammary gland are far from completely understood. Furthermore, the implications of calcium signaling in terms of reaulating proliferation, differentiation and apoptosis in the breast are currently uncertain. Deregulation of calcium homeostasis and signaling is associated with mammary gland pathophysiology and as such, calcium transporters, channels and binding proteins represent potential drug targets for the treatment of breast cancer. (c) 2005 Elsevier B.V. All rights reserved.

Identificador

http://espace.library.uq.edu.au/view/UQ:79642

Idioma(s)

eng

Publicador

Elsevier

Palavras-Chave #Biochemistry & Molecular Biology #Biophysics #Oncology #Plasma-membrane Ca2+-atpase #Yeast Secretory Pathway #Hailey-hailey-disease #Metastasis-inducing Protein #Capacitative Ca2+ Entry #Hormone-related Protein #Estrogen-receptor-beta #Selective Ion-channel #Endoplasmic-reticulum #Intracellular Calcium #C1 #320501 Pharmaceutical Sciences and Pharmacy #780105 Biological sciences
Tipo

Journal Article