Biomolecular engineering at interfaces


Autoria(s): He, L. Z.; Dexter, A. F.; Middelberg, A. P. J.
Contribuinte(s)

A. Bell (Editor-in-Chief)

Data(s)

01/01/2006

Resumo

A broad review of technologically focused work concerning biomolecules at interfaces is presented. The emphasis is on developments in interfacial biomolecular engineering that may have a practical impact in bioanalysis, tissue engineering, emulsion processing or bioseparations. We also review methods for fabrication in an attempt to draw out those approaches that may be useful for product manufacture, and briefly review methods for analysing the resulting interfacial nanostructures. From this review we conclude that the generation of knowledge and-innovation at the nanoscale far exceeds our ability to translate this innovation into practical outcomes addressing a market need, and that significant technological challenges exist. A particular challenge in this translation is to understand how the structural properties of biomolecules control the assembled architecture, which in turn defines product performance, and how this relationship is affected by the chosen manufacturing route. This structure-architecture-process-performance (SAPP) interaction problem is the familiar laboratory scale-up challenge in disguise. A further challenge will be to interpret biomolecular self- and directed-assembly reactions using tools of chemical reaction engineering, enabling rigorous manufacturing optimization of self-assembly laboratory techniques. We conclude that many of the technological problems facing this field are addressable using tools of modem chemical and biomolecular engineering, in conjunction with knowledge and skills from the underpinning sciences. (c) 2005 Elsevier Ltd. All rights reserved.

Identificador

http://espace.library.uq.edu.au/view/UQ:78802

Idioma(s)

eng

Publicador

Pergamon-elsevier Science Ltd

Palavras-Chave #Engineering, Chemical #Biomolecule #Protein #Interface #Analysis #Self-assembly #Processing #Dip-pen Nanolithography #Self-assembled Monolayers #Sum-frequency Generation #Langmuir-blodgett-films #By-layer Construction #Cell-adhesion #Single-molecule #Thin-films #Hexadecane/water Interface #Fluorescence Spectroscopy #C1 #290699 Chemical Engineering not elsewhere classified #291804 Nanotechnology #299999 Engineering and Technology not elsewhere classified #670499 Other #670799 Other #670199 Processed food products and beverages not elsewhere classified
Tipo

Journal Article