NF-gamma B - a target in the inflammation of bone destruction
Data(s) |
01/02/2005
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Resumo |
NF-kappaB activation is associatied with the inflammation of bone destruction and certain cancers. The NEMO (NF-kB essential modulator)-binding domain (NBD) protein inhibits the activation of NF-kappaB. Cellular studies have shown that the NBD protein inhibits osteoclastogenesis. Mimicking infection with a lipopolysaccharide injection in mice resulted in activated osteoclasts and reduced bone mineral density. These responses are inhibited with the NBD peptide. In a mouse model of rheumatoid arthritis, collagen-induced arthritis, treatment with the NBD protein delayed the onset, lowered the incidence and decreased the severity of the arthritis. NF-kappaB is a target in the inflammation associated with bone destruction. A key issue is whether or not this important transcription factor can be inhibited without causing excessive adverse effects and/or toxicity. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Ashley Publications Ltd |
Palavras-Chave | #Bone Destruction #Inflammation #Nemo-binding Domain (nbd) Protein #Nf-kappa B #Rheumatoid Arthritis (ra) #Pharmacology & Pharmacy #Selective-inhibition #In-vivo #Blocks #Cancer #C1 #11 Medical and Health Sciences #1115 Pharmacology and Pharmaceutical Sciences |
Tipo |
Journal Article |