NF-gamma B - a target in the inflammation of bone destruction


Autoria(s): Doggrell, Sheila A.
Data(s)

01/02/2005

Resumo

NF-kappaB activation is associatied with the inflammation of bone destruction and certain cancers. The NEMO (NF-kB essential modulator)-binding domain (NBD) protein inhibits the activation of NF-kappaB. Cellular studies have shown that the NBD protein inhibits osteoclastogenesis. Mimicking infection with a lipopolysaccharide injection in mice resulted in activated osteoclasts and reduced bone mineral density. These responses are inhibited with the NBD peptide. In a mouse model of rheumatoid arthritis, collagen-induced arthritis, treatment with the NBD protein delayed the onset, lowered the incidence and decreased the severity of the arthritis. NF-kappaB is a target in the inflammation associated with bone destruction. A key issue is whether or not this important transcription factor can be inhibited without causing excessive adverse effects and/or toxicity.

Identificador

http://espace.library.uq.edu.au/view/UQ:76279

Idioma(s)

eng

Publicador

Ashley Publications Ltd

Palavras-Chave #Bone Destruction #Inflammation #Nemo-binding Domain (nbd) Protein #Nf-kappa B #Rheumatoid Arthritis (ra) #Pharmacology & Pharmacy #Selective-inhibition #In-vivo #Blocks #Cancer #C1 #11 Medical and Health Sciences #1115 Pharmacology and Pharmaceutical Sciences
Tipo

Journal Article