Calbistrin E and two other new metabolites from an Australian isolate of Penicillium striatisporum
Data(s) |
01/01/2005
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Resumo |
An Australian isolate of Penicillium striatisporum collected near Shalvey, New South Wales, exhibited selective antifungal activity against Candida albicans versus Saccharomyces cerevisiae. Bioassay-directed fractionation yielded members of the rare class of fungal metabolites known as the calbistrins. These included a new example of this structure class, calbistrin E (1), as well as the known polyenes calbistrin C (2) and deformylcalbistrin A (3). Also recovered from P. striatisporum were new triene and butenolide acids, striatisporin A (4) and striatisporolide A (5), together with the known fungal metabolites versiol (6) and (+)-hexylitaconic acid (7). Structures for all metabolites were determined by detailed spectroscopic analysis. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Amer Chemical Soc |
Palavras-Chave | #Plant Sciences #Chemistry, Applied #Chemistry, Medicinal #Pharmacology & Pharmacy #Fungal Metabolite #Antifungal Agent #Restrictum #Elucidation #C1 #250300 Organic Chemistry #780103 Chemical sciences #030401 Biologically Active Molecules #030502 Natural Products Chemistry |
Tipo |
Journal Article |