Opioids Inhibit Lateral Amygdala Pyramidal Neurons by Enhancing A Dendritic Potassium Current
Contribuinte(s) |
Gary L. Westbrook |
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Data(s) |
01/01/2004
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Resumo |
Pyramidal neurons in the lateral amygdala discharge trains of action potentials that show marked spike frequency adaptation, which is primarily mediated by activation of a slow calcium-activated potassium current. We show here that these neurons also express an alpha-dendrotoxin- and tityustoxin-Kalpha-sensitive voltage-dependent potassium current that plays a key role in the control of spike discharge frequency. This current is selectively targeted to the primary apical dendrite of these neurons. Activation of mu-opioid receptors by application of morphine or D-Ala(2)-N-Me-Phe(4)-Glycol(5)-enkephalin (DAMGO) potentiates spike frequency adaptation by enhancing the alpha-dendrotoxin-sensitive potassium current. The effects of mu-opioid agonists on spike frequency adaptation were blocked by inhibiting G-proteins with N-ethylmaleimide (NEM) and by blocking phospholipase A(2). Application of arachidonic acid mimicked the actions of DAMGO or morphine. These results show that mu-opioid receptor activation enhances spike frequency adaptation in lateral amygdala neurons by modulating a voltage-dependent potassium channel containing Kv1.2 subunits, through activation of the phospholipase A(2)-arachidonic acid-lipoxygenases cascade. |
Identificador |
http://espace.library.uq.edu.au/view/UQ:74427/UQ74427_OA.pdf |
Idioma(s) |
eng |
Publicador |
Society for Neuroscience |
Palavras-Chave | #Anxiolytic #Arachidonic #Channel #Nociception #Pain #Lipoxygenase #Kvl.2 #Long-term Potentiation #Tityustoxin-k-alpha #Periaqueductal Gray #Basolateral Amygdala #Hippocampal-neurons #Receptor Activation #Cortical-neurons #Arachidonic-acid #Rat-brain #Channels #Neurosciences #C1 #320702 Central Nervous System #730104 Nervous system and disorders |
Tipo |
Journal Article |